Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum

doi:10.3390/molecules24122206

	Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum
	Zhang, Dongdong 1,2,3; Fu, Yao 1,2,3; Yang, Jun 1,2,3; Li, Xiao-Nian 2,3; San, Myint Myint 4; Oo, Thaung Naing 4; Wang, Yuehu1,2,3 ; Yang, Xuefei1,2,3
通讯作者	Wang, Yuehu(wangyuehu@mail.kib.ac.cn) ; Yang, Xuefei(xuefei@mail.kib.ac.cn)
	2019-06-02
发表期刊	MOLECULES
ISSN	1420-3049
卷号	24 期号:12 页码:23
摘要	Four new triterpenoids, 3 beta,12 beta,16 beta,21 beta,22-pentahydroxyhopane (1), 12 beta,16 beta,21 beta,22-tetrahydroxyhopan-3-one (2), 3-oxo-olean-12-ene-28,30-dioic acid (3), and 3 beta-hydroxyoleana-11,13(18)-diene-28,30-dioic acid 30-methyl ester (4); 21 new triterpenoid saponins, glinusopposides A-U (5-25); and 12 known compounds (26-37) were isolated from the whole plants of Glinus oppositifolius. The structures of the new compounds were elucidated based on the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. All compounds from the plants were measured for antifungal activities against Microsporum gypseum and Trichophyton rubrum. Glinusopposide B (6), glinusopposide Q (21), glinusopposide T (24), and glinusopposide U (25) showed strong inhibitory activities against M. gypseum (MIC50 7.1, 6.7, 6.8, and 11.1 mu M, respectively) and T. rubrum (MIC50 14.3, 13.4, 11.9, and 13.0 mu M, respectively). For those active compounds with an oleanane skeleton, glycosylation (21-26) or oxidation (3) of 3-OH was helpful in increasing the activity; replacement of the 30-methyl group (29) by a carboxymethyl group (26) enhanced the activity; the presence of 11,13(18) double bonds (20) decreased the activity.
关键词	Glinus oppositifolius triterpenoids and triterpenoid saponins antifungal activity
DOI	10.3390/molecules24122206
收录类别	SCI
语种	英语
WOS记录号	WOS:000473816900012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67885
专题	资源植物与生物技术所级重点实验室
通讯作者	Wang, Yuehu; Yang, Xuefei
作者单位	1.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Forest Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
推荐引用方式 GB/T 7714	Zhang, Dongdong,Fu, Yao,Yang, Jun,et al. Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum[J]. MOLECULES,2019,24(12):23.
APA	Zhang, Dongdong.,Fu, Yao.,Yang, Jun.,Li, Xiao-Nian.,San, Myint Myint.,...&Yang, Xuefei.(2019).Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum.MOLECULES,24(12),23.
MLA	Zhang, Dongdong,et al."Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum".MOLECULES 24.12(2019):23.

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