Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides
Tu, Wen-Chao1,2,3; Qi, Yan-Yan1; Ding, Lin-Fen2,3; Yang, Hui1,2,3; Liu, Jiang-Xin1; Peng, Li-Yan1; Song, Liu-Dong2,3; Gong, Xun1; Wu, Xing-De1; Zhao, Qin-Shi1
Corresponding AuthorWu, Xing-De(wuxingde@mail.kib.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
2019-05-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume161Pages:86-96
AbstractA phytochemical study on the stem bark of Metasequoia glyptostroboides led to the isolation of sixty-one diterpenoids and sesquiterpenoids, including seventeen previously undescribed compounds, metaglyptins A-Q. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, and H-1, C-13 and 2D NMR). The absolute configurations of metaglyptins I, J, and O were determined by the ECD data and single-crystal X-ray diffraction analysis. The undescribed compounds were evaluated for their cytotoxicity against HeLa, AGS, and MDA-MB-231 cancer cell lines. The results revealed that metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line with IC50 value of 20.02 mu M.
KeywordMetasequoia glyptostroboides Hu & WC Cheng Cupressaceae Sesquiterpenoids Diterpenoids Cytotoxicity
DOI10.1016/j.phytochem.2019.02.008
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000465062600007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67601
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWu, Xing-De; Zhao, Qin-Shi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Tu, Wen-Chao,Qi, Yan-Yan,Ding, Lin-Fen,et al. Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides[J]. PHYTOCHEMISTRY,2019,161:86-96.
APA Tu, Wen-Chao.,Qi, Yan-Yan.,Ding, Lin-Fen.,Yang, Hui.,Liu, Jiang-Xin.,...&Zhao, Qin-Shi.(2019).Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides.PHYTOCHEMISTRY,161,86-96.
MLA Tu, Wen-Chao,et al."Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides".PHYTOCHEMISTRY 161(2019):86-96.
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