| Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides | |
Tu, Wen-Chao1,2,3; Qi, Yan-Yan1; Ding, Lin-Fen2,3; Yang, Hui1,2,3; Liu, Jiang-Xin1; Peng, Li-Yan1; Song, Liu-Dong2,3; Gong, Xun1 ; Wu, Xing-De1; Zhao, Qin-Shi1
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| 通讯作者 | Wu, Xing-De(wuxingde@mail.kib.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn) |
| 2019-05-01 | |
| 发表期刊 | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| 卷号 | 161页码:86-96 |
| 摘要 | A phytochemical study on the stem bark of Metasequoia glyptostroboides led to the isolation of sixty-one diterpenoids and sesquiterpenoids, including seventeen previously undescribed compounds, metaglyptins A-Q. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, and H-1, C-13 and 2D NMR). The absolute configurations of metaglyptins I, J, and O were determined by the ECD data and single-crystal X-ray diffraction analysis. The undescribed compounds were evaluated for their cytotoxicity against HeLa, AGS, and MDA-MB-231 cancer cell lines. The results revealed that metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line with IC50 value of 20.02 mu M. |
| 关键词 | Metasequoia glyptostroboides Hu & WC Cheng Cupressaceae Sesquiterpenoids Diterpenoids Cytotoxicity |
| DOI | 10.1016/j.phytochem.2019.02.008 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000465062600007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67601 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wu, Xing-De; Zhao, Qin-Shi |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tu, Wen-Chao,Qi, Yan-Yan,Ding, Lin-Fen,et al. Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides[J]. PHYTOCHEMISTRY,2019,161:86-96. |
| APA | Tu, Wen-Chao.,Qi, Yan-Yan.,Ding, Lin-Fen.,Yang, Hui.,Liu, Jiang-Xin.,...&Zhao, Qin-Shi.(2019).Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides.PHYTOCHEMISTRY,161,86-96. |
| MLA | Tu, Wen-Chao,et al."Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides".PHYTOCHEMISTRY 161(2019):86-96. |
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| Tu-2019-Diterpenoids（1045KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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