Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis
Zheng, Wenqi1; Zhou, Lutan2,3; Lin, Lisha2,3; Cai, Ying2,3; Sun, Huifang2,3; Zhao, Longyan1; Gao, Na1; Yin, Ronghua2; Zhao, Jinhua1,2
Corresponding AuthorYin, Ronghua(yinronghua@mail.kib.ac.cn) ; Zhao, Jinhua(zhao.jinhua@yahoo.com)
2019-04-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:4Pages:15
AbstractSulfated polysaccharides from sea cucumbers possess distinct chemical structure and various biological activities. Herein, three types of polysaccharides were isolated and purified from Pattalus mollis, and their structures and bioactivities were analyzed. The fucosylated glycosaminoglycan (PmFG) had a CS-like backbone composed of the repeating units of {-4-d-GlcA--1,3-d-GalNAc(4S6S)--1-}, and branches of a sulfated -l-Fuc (including Fuc(2S4S), Fuc(3S4S) and Fuc(4S) with a molar ratio of 2:2.5:1) linked to O-3 of each d-GlcA. The fucan sulfate (PmFS) had a backbone consisting of a repetitively linked unit {-4-l-Fuc(2S)--1-}, and interestingly, every trisaccharide unit in its backbone was branched with a sulfated -l-Fuc (Fuc(4S) or Fuc(3S) with a molar ratio of 4:1). Apart from the sulfated polysaccharides, two neutral glycans (PmNG-1 & -2) differing in molecular weight were also obtained and their structures were similar to animal glycogen. Anticoagulant assays indicated that PmFG and PmFS possessed strong APTT prolonging and intrinsic factor Xase inhibition activities, and the sulfated -l-Fuc branches might contribute to the anticoagulant and anti-FXase activities of both PmFG and PmFS.
KeywordPattalus mollis fucosylated glycosaminoglycan fucan sulfate physicochemical characteristics anticoagulant activities
DOI10.3390/md17040198
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000467307100005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/66912
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorYin, Ronghua; Zhao, Jinhua
Affiliation1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Wenqi,Zhou, Lutan,Lin, Lisha,et al. Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis[J]. MARINE DRUGS,2019,17(4):15.
APA Zheng, Wenqi.,Zhou, Lutan.,Lin, Lisha.,Cai, Ying.,Sun, Huifang.,...&Zhao, Jinhua.(2019).Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis.MARINE DRUGS,17(4),15.
MLA Zheng, Wenqi,et al."Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis".MARINE DRUGS 17.4(2019):15.
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