Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.

	Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.
	Gao, Yuan; Niu, Yan-Fen; Wang, Fei; Hai, Ping; Wang, Fang; Fang, Yin-Dong; Xiong, Wen-Yong; Liu, Ji-Kai
	2016
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	6 期号:5 页码:247-255
摘要	Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64870
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Gao, Yuan,Niu, Yan-Fen,Wang, Fei,et al. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.[J]. Natural products and bioprospecting,2016,6(5):247-255.
APA	Gao, Yuan.,Niu, Yan-Fen.,Wang, Fei.,Hai, Ping.,Wang, Fang.,...&Liu, Ji-Kai.(2016).Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa..Natural products and bioprospecting,6(5),247-255.
MLA	Gao, Yuan,et al."Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.".Natural products and bioprospecting 6.5(2016):247-255.