| Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS | |
Hu, Jing1,2,3; Li, Xingren1,2; Tian, Weifeng1,2; Lu, Yanting1,2; Xu, Yuhui1,2,3; Wang, Fang1,2,3; Qin, Wanying1,2; Ma, Xiuli1,2; Puno, Pema-Tenzin1,3 ; Xiong, Wenyong1,3
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| 2019 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 24期号:1页码:16 |
| 摘要 | Adenanthin, a natural ent-kaurane diterpenoid extracted from the herb Isodon adenantha, has been reported to increase intracellular reactive oxygen species in leukemic and hepatocellular carcinoma cells. However, the function and mechanism of the compound in adipogenesis and the development of obesity is still unknown. In this study, we demonstrated that adenanthin inhibited adipogenesis of 3T3-L1 and mouse embryonic fibroblasts, and the underlying mechanism included two processes: a delayed mitotic clonal expansion via G0/G1 cell cycle arrest by inhibiting the RB-E2F1 signaling pathway and a reduced C/EBP signaling by inhibiting the expression and activity of C/EBP during mitotic clonal expansion. Furthermore, adenanthin significantly reduced the growing body weight and adipose tissue mass during high-fat diet-inducing obesity of mice, indicating the beneficial effects of adenanthin as a potential agent for prevention of obesity. |
| 关键词 | adenanthin adipogenesis reactive oxygen species obesity 3T3-L1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/64460 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Puno, Pema-Tenzin; Xiong, Wenyong |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Jing,Li, Xingren,Tian, Weifeng,et al. Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS[J]. MOLECULES,2019,24(1):16. |
| APA | Hu, Jing.,Li, Xingren.,Tian, Weifeng.,Lu, Yanting.,Xu, Yuhui.,...&Xiong, Wenyong.(2019).Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS.MOLECULES,24(1),16. |
| MLA | Hu, Jing,et al."Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS".MOLECULES 24.1(2019):16. |
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