New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense

	New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense
	Xu, Shao-Hua 1; Xu, Wen 1; Wang, Li 1,2; Hu, Yi-Kao 1; Liu, Jin-Ping 1; Zhao, Yan 1; Li, Meng-Jia 1; Li, Feng 1; Huang, Sheng-Xiong2 ; Zhao, Yong 1
	2018-11-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	131 页码:141-145
摘要	Five new phloroglucinol derivatives (1-5) together with one known analogue (6) were isolated from the leaves of Syzygiwn austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A - E (1-5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and ID and 2D nuclear magnetic resonance (NMR). Compounds 4-6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. This discovery of new phloroglucinols and their bioactivities provided a scientific basis for the application of S. austroyunnanense as an edible and medicinal plant.
关键词	Syzygium austroyunnanense Myrtaceae Phloroglucinol derivatives Structure elucidation PTP 1B inhibitory activities
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64298
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Huang, Sheng-Xiong; Zhao, Yong
作者单位	1.Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Xu, Shao-Hua,Xu, Wen,Wang, Li,et al. New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense[J]. FITOTERAPIA,2018,131:141-145.
APA	Xu, Shao-Hua.,Xu, Wen.,Wang, Li.,Hu, Yi-Kao.,Liu, Jin-Ping.,...&Zhao, Yong.(2018).New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense.FITOTERAPIA,131,141-145.
MLA	Xu, Shao-Hua,et al."New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense".FITOTERAPIA 131(2018):141-145.