Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18
Tang, Jian-Wei1,2,3; Kong, Ling-Mei1,2; Zu, Wen-Yu4; Hu, Kun1,2; Li, Xiao-Nian1,2; Yan, Bing-Chao1,2; Wang, Wei-Guang1,2; Sun, Han-Dong1,2; Li, Yan1,2; Puno, Pema-Tenzin1,2
2019-02-01
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:3Pages:771-775
AbstractIsopenicins A-C (1-3), three novel meroterpenoids possessing two types of unprecedented terpenoid-polyketide hybrid skeletons, were isolated from the cultures of Penicillium sp. sh18. Their structures were determined through synergetic use of extensive spectroscopic analysis, quantum-chemical calculation with ANN-PRA analysis, and X-ray crystallographic analysis. Additionally, the inhibitory activities of these compounds on the Wnt/beta-catenin signaling pathway were evaluated, and 1 was identified as a potent inhibitor of the Wnt signaling pathway.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64236
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Yan; Puno, Pema-Tenzin
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Tang, Jian-Wei,Kong, Ling-Mei,Zu, Wen-Yu,et al. Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18[J]. ORGANIC LETTERS,2019,21(3):771-775.
APA Tang, Jian-Wei.,Kong, Ling-Mei.,Zu, Wen-Yu.,Hu, Kun.,Li, Xiao-Nian.,...&Puno, Pema-Tenzin.(2019).Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18.ORGANIC LETTERS,21(3),771-775.
MLA Tang, Jian-Wei,et al."Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18".ORGANIC LETTERS 21.3(2019):771-775.
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