Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase-IV
Hou, Bo1,2,3; Kuang, Meng-Ting1,2,3; Chi, Xiao-Qian1,2,3; Li, Jin-Yu1,2,3; Yang, Liu1,2,3; Liu, Zhen-Hua1,2; Yuan, Ming-Yan1,2; Kong, Qing-Hua1,2; Hu, Jiang-Miao1,2; Zhou, Jun1,2
2018-10-24
Source PublicationCHEMISTRYSELECT
ISSN2365-6549
Volume3Issue:39Pages:10864-10868
AbstractType 2 diabetes was usually caused by inadequate secretion of insulin or insulin resistance in tissues and organs. About 90% diabetes belongs to type 2 diabetes, which is seriously harmful to human health. Dipeptidyl Peptidase-IV (DPP-IV) target have attracted much attention because of its ability to prevent type 2 diabetes (T2D). Clinical application of chemical synthetic medicines has different degrees of side effects. Therefore, the present evaluation aims to seek DPP-IV inhibitors as the source of natural products. DPP-IV inhibitory activities of eight natural products and a structural modification of mangostin (eight chromone of 1-8 and iridoid glycoside for 9) were evaluated by this manuscript at the enzyme level. As a result, three chromones of 2 (a modified mangostin), 3 (mangiferin) and 5 (breviscapin) showed moderate DPP-IV inhibitory activities with IC50 values of 69.27M, 44.19M, and 49.53M via the use of the fluorescence-based method (0.25mM, 0.34mM and 0.85mM for the chromogenic substrate method). This study suggests that natural products, which mainly consist by chromone that generated from Mango and Scutellaria baicalensis may have beneficial effects on treating T2D.
KeywordDPP-IV inhibitors Scutellaria baicalensis Mango Natural products Virtual Screening
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/63095
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHu, Jiang-Miao; Zhou, Jun
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Hou, Bo,Kuang, Meng-Ting,Chi, Xiao-Qian,et al. Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase-IV[J]. CHEMISTRYSELECT,2018,3(39):10864-10868.
APA Hou, Bo.,Kuang, Meng-Ting.,Chi, Xiao-Qian.,Li, Jin-Yu.,Yang, Liu.,...&Zhou, Jun.(2018).Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase-IV.CHEMISTRYSELECT,3(39),10864-10868.
MLA Hou, Bo,et al."Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase-IV".CHEMISTRYSELECT 3.39(2018):10864-10868.
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