LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities

	LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities
	Xu, Hong-Bo 1; Yang, Tong-Hua 2; Xie, Pei 1; Tang, Zhi-Shu 1; Song, Xiao 3; Xu, Huai-Li 1; Li, Yan-Hong 4; Zhang, Dong-Bo 1; Liu, Yan-Ru 1; Liang, Yan-Ni 1; Zhang, Yu1 ; Liu, Shi-Jun 1; Wei, Si-Min 1; Sun, Chen 1; Liu, Hong-Bo 1; Deng, Chong 3; Wang, Wei3
	2018-10-01
Source Publication	FITOTERAPIA
ISSN	0367-326X
Volume	130 Pages:265-271
Abstract	Gracilistones A (1) and B (2), two new eudesmane-type sesquiterpenoids with an unusual tetrahydrofuran-fused 6/6/5 tricyclic ring system, were obtained from Acanthopanax gracilistylus under the guidance of LC-MS investigation. Their structures and absolute configurations were assigned by extensive spectroscopic analyses and quantum calculation methods. Compounds 1 and 2 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, compared with the positive control L-NMMA. In addition, compounds 1 and 2 were also evaluated for their antioxidant (DPPH center dot and ABTS(center dot)(+)) and xanthine oxidase (XO) inhibitory activities, and they exhibited weak inhibitory effects at 100 mu M.
Keyword	Acanthopanax gracilistylus Eudesmane-type sesquiterpenoid LC-MS Anti-inflammation Anti-oxidant Xanthine oxidase
Language	英语
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/63087
Collection	植物化学与西部植物资源持续利用国家重点实验室
Corresponding Author	Tang, Zhi-Shu; Deng, Chong; Wang, Wei
Affiliation	1.Shaanxi Univ Chinese Med, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Shaanxi Prov Key Lab New Drugs & Chinese Med Fdn, Xianyang 712046, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Peoples R China 4.Northwest Univ, Dept Ophthalmol, Affiliated Hosp 1, Xian 710004, Shaanxi, Peoples R China
Recommended Citation GB/T 7714	Xu, Hong-Bo,Yang, Tong-Hua,Xie, Pei,et al. LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities[J]. FITOTERAPIA,2018,130:265-271.
APA	Xu, Hong-Bo.,Yang, Tong-Hua.,Xie, Pei.,Tang, Zhi-Shu.,Song, Xiao.,...&Wang, Wei.(2018).LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities.FITOTERAPIA,130,265-271.
MLA	Xu, Hong-Bo,et al."LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities".FITOTERAPIA 130(2018):265-271.

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