LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities
Xu, Hong-Bo1; Yang, Tong-Hua2; Xie, Pei1; Tang, Zhi-Shu1; Song, Xiao3; Xu, Huai-Li1; Li, Yan-Hong4; Zhang, Dong-Bo1; Liu, Yan-Ru1; Liang, Yan-Ni1; Zhang, Yu1; Liu, Shi-Jun1; Wei, Si-Min1; Sun, Chen1; Liu, Hong-Bo1; Deng, Chong3; Wang, Wei3
2018-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号130页码:265-271
摘要Gracilistones A (1) and B (2), two new eudesmane-type sesquiterpenoids with an unusual tetrahydrofuran-fused 6/6/5 tricyclic ring system, were obtained from Acanthopanax gracilistylus under the guidance of LC-MS investigation. Their structures and absolute configurations were assigned by extensive spectroscopic analyses and quantum calculation methods. Compounds 1 and 2 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, compared with the positive control L-NMMA. In addition, compounds 1 and 2 were also evaluated for their antioxidant (DPPH center dot and ABTS(center dot)(+)) and xanthine oxidase (XO) inhibitory activities, and they exhibited weak inhibitory effects at 100 mu M.
关键词Acanthopanax gracilistylus Eudesmane-type sesquiterpenoid LC-MS Anti-inflammation Anti-oxidant Xanthine oxidase
资助信息program of National Natural Science Foundation of China; Key Science Technology Innovation Team Project of Shaanxi province; key culture project of Shaanxi University of Chinese Medicine
语种英语
资助项目program of National Natural Science Foundation of China[81603284] ; Key Science Technology Innovation Team Project of Shaanxi province[2012KTC-20] ; key culture project of Shaanxi University of Chinese Medicine[2016PY15]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/63087
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Tang, Zhi-Shu; Deng, Chong; Wang, Wei
作者单位1.Shaanxi Univ Chinese Med, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Shaanxi Prov Key Lab New Drugs & Chinese Med Fdn, Xianyang 712046, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
3.Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Peoples R China
4.Northwest Univ, Dept Ophthalmol, Affiliated Hosp 1, Xian 710004, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714
Xu, Hong-Bo,Yang, Tong-Hua,Xie, Pei,et al. LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities[J]. FITOTERAPIA,2018,130:265-271.
APA Xu, Hong-Bo.,Yang, Tong-Hua.,Xie, Pei.,Tang, Zhi-Shu.,Song, Xiao.,...&Wang, Wei.(2018).LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities.FITOTERAPIA,130,265-271.
MLA Xu, Hong-Bo,et al."LC-MS guided isolation of gracilistones A and B, a pair of diastereomeric sesquiterpenoids with an unusual tetrahydrofuran-fused tricyclic skeleton from Acanthopanax gracilistylus and their potential anti-inflammatory activities".FITOTERAPIA 130(2018):265-271.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Hong-Bo]的文章
[Yang, Tong-Hua]的文章
[Xie, Pei]的文章
百度学术
百度学术中相似的文章
[Xu, Hong-Bo]的文章
[Yang, Tong-Hua]的文章
[Xie, Pei]的文章
必应学术
必应学术中相似的文章
[Xu, Hong-Bo]的文章
[Yang, Tong-Hua]的文章
[Xie, Pei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。