| BACE1 Inhibitory Meroterpenoids from Aspergillus terreus | |
| Qi, Changxing1; Liu, Mengting1; Zhou, Qun1; Gao, Weixi1; Chen, Chunmei1; Lai, Yongji2; Hu, Zhengxi1; Xue, Yongbo1; Zhang, Jinwen3; Li, Dongyan3; Li, Xiao-Nian4; Zhang, Qing1; Wang, Jianping1; Zhu, Hucheng1; Zhang, Yonghui1 | |
| 2018-09-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 81Issue:9Pages:1937-1945 |
| Abstract | Sixteen 3,5-dimethylorsellinic acid-based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D-M (1-10), were obtained from Aspergillus terreus. The structures and absolute configurations of the new compounds were confirmed by extensive spectroscopy, single-crystal X-ray diffraction analysis, and experimental electronic circular dichroism (ECD) measurements. Compounds 2, 3, and 7 are the first 3,5-dimethylorsellinic acid-based meroterpenoids possessing a unique cis-fused A/B ring system. These new compounds were evaluated for their inhibitory activity against beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Compounds 2, 3, and 7, the first 3,5-dimethylorsellinic acid based meroterpenoids possessing cis-fused A/B rings, exhibited significant inhibitory activities against BACE1 with IC50 values of 3.3, 5.9, and 31.7 mu M, respectively. |
| DOI | 10.1021/acs.jnatprod.7b01050 |
| Language | 英语 |
| WOS ID | WOS:000446276600003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/62789 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Wang, Jianping; Zhu, Hucheng; Zhang, Yonghui |
| Affiliation | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430030, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Qi, Changxing,Liu, Mengting,Zhou, Qun,et al. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1937-1945. |
| APA | Qi, Changxing.,Liu, Mengting.,Zhou, Qun.,Gao, Weixi.,Chen, Chunmei.,...&Zhang, Yonghui.(2018).BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.JOURNAL OF NATURAL PRODUCTS,81(9),1937-1945. |
| MLA | Qi, Changxing,et al."BACE1 Inhibitory Meroterpenoids from Aspergillus terreus".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1937-1945. |
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