BACE1 Inhibitory Meroterpenoids from Aspergillus terreus

doi:10.1021/acs.jnatprod.7b01050

	BACE1 Inhibitory Meroterpenoids from Aspergillus terreus
	Qi, Changxing 1; Liu, Mengting 1; Zhou, Qun 1; Gao, Weixi 1; Chen, Chunmei 1; Lai, Yongji 2; Hu, Zhengxi 1; Xue, Yongbo 1; Zhang, Jinwen 3; Li, Dongyan 3; Li, Xiao-Nian 4; Zhang, Qing 1; Wang, Jianping 1; Zhu, Hucheng 1; Zhang, Yonghui 1
	2018-09-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:9 页码:1937-1945
摘要	Sixteen 3,5-dimethylorsellinic acid-based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D-M (1-10), were obtained from Aspergillus terreus. The structures and absolute configurations of the new compounds were confirmed by extensive spectroscopy, single-crystal X-ray diffraction analysis, and experimental electronic circular dichroism (ECD) measurements. Compounds 2, 3, and 7 are the first 3,5-dimethylorsellinic acid-based meroterpenoids possessing a unique cis-fused A/B ring system. These new compounds were evaluated for their inhibitory activity against beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Compounds 2, 3, and 7, the first 3,5-dimethylorsellinic acid based meroterpenoids possessing cis-fused A/B rings, exhibited significant inhibitory activities against BACE1 with IC50 values of 3.3, 5.9, and 31.7 mu M, respectively.
DOI	10.1021/acs.jnatprod.7b01050
语种	英语
WOS记录号	WOS:000446276600003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62789
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Wang, Jianping; Zhu, Hucheng; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430030, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Qi, Changxing,Liu, Mengting,Zhou, Qun,et al. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1937-1945.
APA	Qi, Changxing.,Liu, Mengting.,Zhou, Qun.,Gao, Weixi.,Chen, Chunmei.,...&Zhang, Yonghui.(2018).BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.JOURNAL OF NATURAL PRODUCTS,81(9),1937-1945.
MLA	Qi, Changxing,et al."BACE1 Inhibitory Meroterpenoids from Aspergillus terreus".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1937-1945.