BACE1 Inhibitory Meroterpenoids from Aspergillus terreus
Qi, Changxing1; Liu, Mengting1; Zhou, Qun1; Gao, Weixi1; Chen, Chunmei1; Lai, Yongji2; Hu, Zhengxi1; Xue, Yongbo1; Zhang, Jinwen3; Li, Dongyan3; Li, Xiao-Nian4; Zhang, Qing1; Wang, Jianping1; Zhu, Hucheng1; Zhang, Yonghui1
2018-09-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:9页码:1937-1945
摘要Sixteen 3,5-dimethylorsellinic acid-based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D-M (1-10), were obtained from Aspergillus terreus. The structures and absolute configurations of the new compounds were confirmed by extensive spectroscopy, single-crystal X-ray diffraction analysis, and experimental electronic circular dichroism (ECD) measurements. Compounds 2, 3, and 7 are the first 3,5-dimethylorsellinic acid-based meroterpenoids possessing a unique cis-fused A/B ring system. These new compounds were evaluated for their inhibitory activity against beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Compounds 2, 3, and 7, the first 3,5-dimethylorsellinic acid based meroterpenoids possessing cis-fused A/B rings, exhibited significant inhibitory activities against BACE1 with IC50 values of 3.3, 5.9, and 31.7 mu M, respectively.
资助信息National Natural Science Foundation of China; Program for Changjiang Scholars; China Postdoctoral Science Foundation; National Science Fund for Distinguished Young Scholars; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST); Innovative Research Groups of the National Natural Science Foundation of China
语种英语
资助项目National Natural Science Foundation of China[81502943] ; National Natural Science Foundation of China[31600266] ; National Natural Science Foundation of China[81573316] ; National Natural Science Foundation of China[21602068] ; National Natural Science Foundation of China[31670354] ; National Natural Science Foundation of China[31370372] ; National Natural Science Foundation of China[21702067] ; Program for Changjiang Scholars[T2016088] ; China Postdoctoral Science Foundation[2018M632879] ; China Postdoctoral Science Foundation[2017M610479] ; National Science Fund for Distinguished Young Scholars[81725021] ; Academic Frontier Youth Team of HUST ; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST) ; Innovative Research Groups of the National Natural Science Foundation of China[81721005]
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62789
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang, Jianping; Zhu, Hucheng; Zhang, Yonghui
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430030, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Hubei, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Qi, Changxing,Liu, Mengting,Zhou, Qun,et al. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1937-1945.
APA Qi, Changxing.,Liu, Mengting.,Zhou, Qun.,Gao, Weixi.,Chen, Chunmei.,...&Zhang, Yonghui.(2018).BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.JOURNAL OF NATURAL PRODUCTS,81(9),1937-1945.
MLA Qi, Changxing,et al."BACE1 Inhibitory Meroterpenoids from Aspergillus terreus".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1937-1945.
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