Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott
Zhang, Tong1; Wang, Li2; Duan, De-Hua1; Zhang, Yi-Hao1; Huang, Sheng-Xiong2; Chang, Ying1
2018-07-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:7页码:11
摘要Dryopteris fragrans is a valuable medicinal plant resource with extensive biological activities including anti-cancer, anti-oxidation, and anti-inflammation activities. This work aims to study further the cytotoxic constituents from Dryopteris fragrans. In this work, two new phenolic derivatives known as dryofragone (1) and dryofracoumarin B (2) with six known compounds (3-8) were isolated from the petroleum ether fraction of the methanol extract of the aerial parts of Dryopteris fragrans (L.) Schott by two round cytotoxicity-guided tracking with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cell counting kit-8 (CCK-8) assay. Their structures were elucidated by the extensive spectroscopic analysis (H-1-NMR, C-13-NMR, and two dimensions NMR), chemical derivatization, and comparison with data reported in the literature. All the isolates were evaluated for their cytotoxicity against nine cancer cell lines as well as their in vitro immunomodulatory activity. The results showed that compounds have a modest cytotoxicity toward human HeLa cell line with IC50 value below 30 mu M and compounds 4 and 5 may modulate immunity to affect the growth of tumor cells.
关键词cytotoxicity-guided phenolic derivatives Dryopteris fragrans chemical derivatization immuno-regulation activity
资助信息National Natural Science Foundation of China; Applied Basic Research Foundation of Yunnan Province; Foundation from Chinese Academy of Sciences
语种英语
资助项目National Natural Science Foundation of China[31570189] ; National Natural Science Foundation of China[81522044] ; Applied Basic Research Foundation of Yunnan Province[2013HA022] ; Foundation from Chinese Academy of Sciences[QYZDB-SSW-SMC051]
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62783
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Huang, Sheng-Xiong; Chang, Ying
作者单位1.Northeast Agr Univ, Coll Life Sci, Harbin 150030, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Zhang, Tong,Wang, Li,Duan, De-Hua,et al. Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott[J]. MOLECULES,2018,23(7):11.
APA Zhang, Tong,Wang, Li,Duan, De-Hua,Zhang, Yi-Hao,Huang, Sheng-Xiong,&Chang, Ying.(2018).Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott.MOLECULES,23(7),11.
MLA Zhang, Tong,et al."Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott".MOLECULES 23.7(2018):11.
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