Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott
Zhang, Tong1; Wang, Li2; Duan, De-Hua1; Zhang, Yi-Hao1; Huang, Sheng-Xiong2; Chang, Ying1
2018-07-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:7Pages:11
AbstractDryopteris fragrans is a valuable medicinal plant resource with extensive biological activities including anti-cancer, anti-oxidation, and anti-inflammation activities. This work aims to study further the cytotoxic constituents from Dryopteris fragrans. In this work, two new phenolic derivatives known as dryofragone (1) and dryofracoumarin B (2) with six known compounds (3-8) were isolated from the petroleum ether fraction of the methanol extract of the aerial parts of Dryopteris fragrans (L.) Schott by two round cytotoxicity-guided tracking with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cell counting kit-8 (CCK-8) assay. Their structures were elucidated by the extensive spectroscopic analysis (H-1-NMR, C-13-NMR, and two dimensions NMR), chemical derivatization, and comparison with data reported in the literature. All the isolates were evaluated for their cytotoxicity against nine cancer cell lines as well as their in vitro immunomodulatory activity. The results showed that compounds have a modest cytotoxicity toward human HeLa cell line with IC50 value below 30 mu M and compounds 4 and 5 may modulate immunity to affect the growth of tumor cells.
Keywordcytotoxicity-guided phenolic derivatives Dryopteris fragrans chemical derivatization immuno-regulation activity
DOI10.3390/molecules23071652
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000445301800155
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62783
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHuang, Sheng-Xiong; Chang, Ying
Affiliation1.Northeast Agr Univ, Coll Life Sci, Harbin 150030, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Tong,Wang, Li,Duan, De-Hua,et al. Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott[J]. MOLECULES,2018,23(7):11.
APA Zhang, Tong,Wang, Li,Duan, De-Hua,Zhang, Yi-Hao,Huang, Sheng-Xiong,&Chang, Ying.(2018).Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott.MOLECULES,23(7),11.
MLA Zhang, Tong,et al."Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott".MOLECULES 23.7(2018):11.
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