Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva

doi:10.1021/acs.orglett.8b02845

	Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva
	Pu, De-Bing1,3 ; Du, Bao-Wen 2; Chen, Wen 1; Gao, Jun-Bo 3; Hu, Kun3 ; Shi, Nan 2; Li, Yi-Ming 1; Zhang, Xing-Jie 1; Zhang, Rui-Han 1; Li, Xiao-Nian 3; Zhang, Hong-Bin 1; Wang, Fei 2; Xiao, Wei-Lie 1,3
	2018-10-05
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	20 期号:19 页码:6314-6317
摘要	Premnafulvol A (1), a unique diterpenoid featuring a 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B-D (2-4), were isolated from the aerial parts of Premna fulva. Structures of 1-4 were established by a combination of extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways of 1-4 were proposed. Interestingly, 2 and 3 exhibited opposite effects on estrogen biosynthesis in human ovarian granulosa-like KGN cells by modulating the expression of aromatase.
DOI	10.1021/acs.orglett.8b02845
语种	英语
WOS记录号	WOS:000447118200072
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62772
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Wang, Fei; Xiao, Wei-Lie
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Pu, De-Bing,Du, Bao-Wen,Chen, Wen,et al. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva[J]. ORGANIC LETTERS,2018,20(19):6314-6317.
APA	Pu, De-Bing.,Du, Bao-Wen.,Chen, Wen.,Gao, Jun-Bo.,Hu, Kun.,...&Xiao, Wei-Lie.(2018).Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva.ORGANIC LETTERS,20(19),6314-6317.
MLA	Pu, De-Bing,et al."Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva".ORGANIC LETTERS 20.19(2018):6314-6317.