Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva
Pu, De-Bing1,3; Du, Bao-Wen2; Chen, Wen1; Gao, Jun-Bo3; Hu, Kun3; Shi, Nan2; Li, Yi-Ming1; Zhang, Xing-Jie1; Zhang, Rui-Han1; Li, Xiao-Nian3; Zhang, Hong-Bin1; Wang, Fei2; Xiao, Wei-Lie1,3
2018-10-05
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号20期号:19页码:6314-6317
摘要Premnafulvol A (1), a unique diterpenoid featuring a 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B-D (2-4), were isolated from the aerial parts of Premna fulva. Structures of 1-4 were established by a combination of extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways of 1-4 were proposed. Interestingly, 2 and 3 exhibited opposite effects on estrogen biosynthesis in human ovarian granulosa-like KGN cells by modulating the expression of aromatase.
资助信息NSFC; Program for Changjiang Scholars and Innovative Research Team in University
语种英语
资助项目NSFC[81422046] ; NSFC[21561142003] ; NSFC[21372214] ; NSFC[21762048] ; NSFC[U1702286] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT_17R94]
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62772
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang, Fei; Xiao, Wei-Lie
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Pu, De-Bing,Du, Bao-Wen,Chen, Wen,et al. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva[J]. ORGANIC LETTERS,2018,20(19):6314-6317.
APA Pu, De-Bing.,Du, Bao-Wen.,Chen, Wen.,Gao, Jun-Bo.,Hu, Kun.,...&Xiao, Wei-Lie.(2018).Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva.ORGANIC LETTERS,20(19),6314-6317.
MLA Pu, De-Bing,et al."Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva".ORGANIC LETTERS 20.19(2018):6314-6317.
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