Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin
Zhou, Qin-Mei1,2; Chen, Ming-Hua3,4; Li, Xiao-Hong1,2; Peng, Cheng1,2; Lin, Da-Sheng5; Li, Xiao-Nian6; He, Yang1; Xiong, Liang1,2
2018-09-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:9Pages:1919-1927
AbstractSeven novel guaiane sesquiterpenoids (1-7) and three known seco-guaianes were isolated from the volatile oil of Pogostemon cablin. Their structures including absolute configurations were determined by spectroscopic analyses, a modified Mosher's method, and X-ray diffraction and ECD data. The results indicated that the ECD Cotton effects arising from one or two nonconjugated olefinic chromophores could be applied to define the absolute configurations of guaiane sesquiterpenoids. Compounds 3 and 6 exhibited significant vasorelaxant activity against phenylephrine-induced and KCl-induced contractions of rat aorta rings [half-maximal effective concentration (EC50) of 3 against PHE-induced contraction, 5.4 mu M; EC50 of 6 against PHE- and KCl-induced contractions, 1.6 and 24.2 mu M, respectively]. They also showed antifungal activity against Candida albicans (minimum inhibitory concentrations, 500 and 300 mu M, respectively). In addition, 2 and 7-9 displayed a neuroprotective effect against glutamate-induced injury in PC12 cells.
DOI10.1021/acs.jnatprod.7b00690
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000446276600001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62767
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorPeng, Cheng; Xiong, Liang
Affiliation1.Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chengdu Taihe Hlth Technol Grp Inc Ltd, Chengdu 610075, Sichuan, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Qin-Mei,Chen, Ming-Hua,Li, Xiao-Hong,et al. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1919-1927.
APA Zhou, Qin-Mei.,Chen, Ming-Hua.,Li, Xiao-Hong.,Peng, Cheng.,Lin, Da-Sheng.,...&Xiong, Liang.(2018).Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin.JOURNAL OF NATURAL PRODUCTS,81(9),1919-1927.
MLA Zhou, Qin-Mei,et al."Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1919-1927.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Qin-Mei]'s Articles
[Chen, Ming-Hua]'s Articles
[Li, Xiao-Hong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Qin-Mei]'s Articles
[Chen, Ming-Hua]'s Articles
[Li, Xiao-Hong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Qin-Mei]'s Articles
[Chen, Ming-Hua]'s Articles
[Li, Xiao-Hong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.