Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin
Zhou, Qin-Mei1,2; Chen, Ming-Hua3,4; Li, Xiao-Hong1,2; Peng, Cheng1,2; Lin, Da-Sheng5; Li, Xiao-Nian6; He, Yang1; Xiong, Liang1,2
2018-09-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:9页码:1919-1927
摘要Seven novel guaiane sesquiterpenoids (1-7) and three known seco-guaianes were isolated from the volatile oil of Pogostemon cablin. Their structures including absolute configurations were determined by spectroscopic analyses, a modified Mosher's method, and X-ray diffraction and ECD data. The results indicated that the ECD Cotton effects arising from one or two nonconjugated olefinic chromophores could be applied to define the absolute configurations of guaiane sesquiterpenoids. Compounds 3 and 6 exhibited significant vasorelaxant activity against phenylephrine-induced and KCl-induced contractions of rat aorta rings [half-maximal effective concentration (EC50) of 3 against PHE-induced contraction, 5.4 mu M; EC50 of 6 against PHE- and KCl-induced contractions, 1.6 and 24.2 mu M, respectively]. They also showed antifungal activity against Candida albicans (minimum inhibitory concentrations, 500 and 300 mu M, respectively). In addition, 2 and 7-9 displayed a neuroprotective effect against glutamate-induced injury in PC12 cells.
资助信息Outstanding Youth Science Foundation of Sichuan Province; National Major Special Project for the Development of New Drugs in China; Scientific Research Fund of Sichuan Provincial Education Department
语种英语
资助项目Outstanding Youth Science Foundation of Sichuan Province[2015JQO030] ; Outstanding Youth Science Foundation of Sichuan Province[2015JQO027] ; National Major Special Project for the Development of New Drugs in China[2017ZX09201001-008-001] ; Scientific Research Fund of Sichuan Provincial Education Department[15ZA0084]
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62767
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Peng, Cheng; Xiong, Liang
作者单位1.Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chengdu Taihe Hlth Technol Grp Inc Ltd, Chengdu 610075, Sichuan, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Zhou, Qin-Mei,Chen, Ming-Hua,Li, Xiao-Hong,et al. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1919-1927.
APA Zhou, Qin-Mei.,Chen, Ming-Hua.,Li, Xiao-Hong.,Peng, Cheng.,Lin, Da-Sheng.,...&Xiong, Liang.(2018).Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin.JOURNAL OF NATURAL PRODUCTS,81(9),1919-1927.
MLA Zhou, Qin-Mei,et al."Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1919-1927.
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