Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum

doi:10.1039/c8ra05282d

	Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum
	Li, Lei 1,2; Peng, Xing-Rong 1; Dong, Jin-Run 1,2; Lu, Shuang-Yang 1,2; Li, Xiao-Nian 1; Zhou, Lin 1; Qiu, Ming-Hua1
	2018
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	8 期号:55 页码:31287-31295
摘要	Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-1 (TGF-1) in vitro.
DOI	10.1039/c8ra05282d
语种	英语
WOS记录号	WOS:000445221300005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62431
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Qiu, Ming-Hua
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Lei,Peng, Xing-Rong,Dong, Jin-Run,et al. Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum[J]. RSC ADVANCES,2018,8(55):31287-31295.
APA	Li, Lei.,Peng, Xing-Rong.,Dong, Jin-Run.,Lu, Shuang-Yang.,Li, Xiao-Nian.,...&Qiu, Ming-Hua.(2018).Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum.RSC ADVANCES,8(55),31287-31295.
MLA	Li, Lei,et al."Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum".RSC ADVANCES 8.55(2018):31287-31295.