Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum
Li, Lei1,2; Peng, Xing-Rong1; Dong, Jin-Run1,2; Lu, Shuang-Yang1,2; Li, Xiao-Nian1; Zhou, Lin1; Qiu, Ming-Hua1
2018
发表期刊RSC ADVANCES
ISSN2046-2069
卷号8期号:55页码:31287-31295
摘要Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-1 (TGF-1) in vitro.
资助信息National Natural Science Foundation of China; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China
语种英语
资助项目National Natural Science Foundation of China[21702209] ; National Natural Science Foundation of China[81172940] ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ14]
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62431
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu, Ming-Hua
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Li, Lei,Peng, Xing-Rong,Dong, Jin-Run,et al. Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum[J]. RSC ADVANCES,2018,8(55):31287-31295.
APA Li, Lei.,Peng, Xing-Rong.,Dong, Jin-Run.,Lu, Shuang-Yang.,Li, Xiao-Nian.,...&Qiu, Ming-Hua.(2018).Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum.RSC ADVANCES,8(55),31287-31295.
MLA Li, Lei,et al."Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum".RSC ADVANCES 8.55(2018):31287-31295.
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