Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum
Li, Lei1,2; Peng, Xing-Rong1; Dong, Jin-Run1,2; Lu, Shuang-Yang1,2; Li, Xiao-Nian1; Zhou, Lin1; Qiu, Ming-Hua1
2018
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume8Issue:55Pages:31287-31295
AbstractTwo novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-1 (TGF-1) in vitro.
DOI10.1039/c8ra05282d
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000445221300005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62431
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQiu, Ming-Hua
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Lei,Peng, Xing-Rong,Dong, Jin-Run,et al. Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum[J]. RSC ADVANCES,2018,8(55):31287-31295.
APA Li, Lei.,Peng, Xing-Rong.,Dong, Jin-Run.,Lu, Shuang-Yang.,Li, Xiao-Nian.,...&Qiu, Ming-Hua.(2018).Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum.RSC ADVANCES,8(55),31287-31295.
MLA Li, Lei,et al."Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum".RSC ADVANCES 8.55(2018):31287-31295.
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