Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis

doi:10.1016/j.bbrc.2018.08.093

	Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis
	Zhu, Huifang 1,2; Wang, Fei 4; Ju, Xiaoman 1,2; Kong, Lingmei 1; An, Tao1 ; Zhao, Zhangxun 1,2; Liu, Jikai 3; Li, Yan1
	2018-09-18
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	503 期号:4 页码:3057-3063
摘要	The natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy. (C) 2018 Elsevier Inc. All rights reserved.
关键词	Aurovertin B Cytotoxicity Immunotherapy NK cell NKG2D ligands
DOI	10.1016/j.bbrc.2018.08.093
语种	英语
WOS记录号	WOS:000444791600129
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62416
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liu, Jikai; Li, Yan
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Hubei, Peoples R China 4.BioBioPha Co Ltd, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Huifang,Wang, Fei,Ju, Xiaoman,et al. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):3057-3063.
APA	Zhu, Huifang.,Wang, Fei.,Ju, Xiaoman.,Kong, Lingmei.,An, Tao.,...&Li, Yan.(2018).Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),3057-3063.
MLA	Zhu, Huifang,et al."Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):3057-3063.