Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis
Zhu, Huifang1,2; Wang, Fei4; Ju, Xiaoman1,2; Kong, Lingmei1; An, Tao1; Zhao, Zhangxun1,2; Liu, Jikai3; Li, Yan1
2018-09-18
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
Volume503Issue:4Pages:3057-3063
AbstractThe natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy. (C) 2018 Elsevier Inc. All rights reserved.
KeywordAurovertin B Cytotoxicity Immunotherapy NK cell NKG2D ligands
DOI10.1016/j.bbrc.2018.08.093
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000444791600129
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62416
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiu, Jikai; Li, Yan
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Hubei, Peoples R China
4.BioBioPha Co Ltd, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Huifang,Wang, Fei,Ju, Xiaoman,et al. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):3057-3063.
APA Zhu, Huifang.,Wang, Fei.,Ju, Xiaoman.,Kong, Lingmei.,An, Tao.,...&Li, Yan.(2018).Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),3057-3063.
MLA Zhu, Huifang,et al."Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):3057-3063.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, Huifang]'s Articles
[Wang, Fei]'s Articles
[Ju, Xiaoman]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, Huifang]'s Articles
[Wang, Fei]'s Articles
[Ju, Xiaoman]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, Huifang]'s Articles
[Wang, Fei]'s Articles
[Ju, Xiaoman]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.