| Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis | |
Zhu, Huifang1,2; Wang, Fei4; Ju, Xiaoman1,2; Kong, Lingmei1; An, Tao1 ; Zhao, Zhangxun1,2; Liu, Jikai3; Li, Yan1
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| 2018-09-18 | |
| Source Publication | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| ISSN | 0006-291X |
| Volume | 503Issue:4Pages:3057-3063 |
| Abstract | The natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy. (C) 2018 Elsevier Inc. All rights reserved. |
| Keyword | Aurovertin B Cytotoxicity Immunotherapy NK cell NKG2D ligands |
| DOI | 10.1016/j.bbrc.2018.08.093 |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Biophysics |
| WOS Subject | Biochemistry & Molecular Biology ; Biophysics |
| WOS ID | WOS:000444791600129 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/62416 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Liu, Jikai; Li, Yan |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Hubei, Peoples R China 4.BioBioPha Co Ltd, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Huifang,Wang, Fei,Ju, Xiaoman,et al. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):3057-3063. |
| APA | Zhu, Huifang.,Wang, Fei.,Ju, Xiaoman.,Kong, Lingmei.,An, Tao.,...&Li, Yan.(2018).Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),3057-3063. |
| MLA | Zhu, Huifang,et al."Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):3057-3063. |
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