Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis
Zhu, Huifang1,2; Wang, Fei4; Ju, Xiaoman1,2; Kong, Lingmei1; An, Tao1; Zhao, Zhangxun1,2; Liu, Jikai3; Li, Yan1
2018-09-18
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
卷号503期号:4页码:3057-3063
摘要The natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy. (C) 2018 Elsevier Inc. All rights reserved.
关键词Aurovertin B Cytotoxicity Immunotherapy NK cell NKG2D ligands
资助信息Exploitation and Utilization of Abundant Natural Products from Plants from Kunming Institute of Botany; National Natural Science Foundation of China; 100 Talents Program of the Chinese Academy of Sciences; Program of Recruited Top Talent of Sciences and Technology of Yunnan Province; Independent Program of Key Laboratory of Natural Pharmaceutical Chemistry of Yunnan Province
DOI10.1016/j.bbrc.2018.08.093
语种英语
资助项目Exploitation and Utilization of Abundant Natural Products from Plants from Kunming Institute of Botany[KIB2017009] ; National Natural Science Foundation of China[U1402227] ; 100 Talents Program of the Chinese Academy of Sciences ; Program of Recruited Top Talent of Sciences and Technology of Yunnan Province[2009CI120] ; Independent Program of Key Laboratory of Natural Pharmaceutical Chemistry of Yunnan Province
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000444791600129
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62416
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu, Jikai; Li, Yan
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Hubei, Peoples R China
4.BioBioPha Co Ltd, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
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Zhu, Huifang,Wang, Fei,Ju, Xiaoman,et al. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):3057-3063.
APA Zhu, Huifang.,Wang, Fei.,Ju, Xiaoman.,Kong, Lingmei.,An, Tao.,...&Li, Yan.(2018).Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),3057-3063.
MLA Zhu, Huifang,et al."Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):3057-3063.
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