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Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis
Qin, Xu-Jie; Ni, Wei; Chen, Chang-Xiang; Liu, Hai-Yang1
2018-10-05
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
卷号224页码:134-139
摘要Ethnopharmacological relevance: The dried rhizomes of Paris polyphylla var. yunnanensis are widely used in traditional Chinese medicine (TCM) as hemostatic, antitumor, and antimicrobial agents. More than 70 Chinese patent medicines are based on P. polyphylla var. yunnanensis rhizomes. Steroidal saponins are considered as the main active ingredients of these rhizomes. However, wild populations of P. polyphylla var. yunnanensis are greatly threatened due to the illegal wild harvest and over-utilization of the rhizomes. In contrast, the renewable above-ground parts (leaves and stems) of P. polyphylla var. yunnanensis are usually thrown away as waste material, whether from wild or cultivated material. Aim of the study: The aim of this study was to use HPLC analyses of chemical constituents and bioactive assays to assess whether the above-ground parts could be an alternative source of active ingredients to the rhizomes of P. polyphylla var. yunnanensis. Materials and methods: The saponin components of the rhizomes and above-ground parts of P. polyphylla var. yunnanensis were analyzed by HPLC-UV. The total saponins extracted from the rhizomes and above-ground parts of P. polyphylla var. yunnanensis were evaluated for their hemostatic, cytotoxic, and antimicrobial activities by using the rabbit blood in vitro based on turbidimetric method, MTT assay method, and a dilution antimicrobial susceptibility test method, respectively. Results: Four bioactive spirostanol saponins (paris saponins I, II, VI, and VII) were detected in the total saponins from the rhizomes and above-ground parts of P. polyphylla var. yunnanensis, which indicated they should have similar pharmacological properties. The bioactive assays revealed that both the parts of P. polyphylla var. yunnanensis exhibited the same hemostatic, cytotoxic, and antimicrobial effects. Conclusion: Our results revealed that based on saponin content in the above-ground parts of P. polyphylla var. yunnanensis and the requirements stipulated in 2015 of Chinese Pharmacopoeia, the above-ground parts (especially its leaves) can be an alternative and more sustainable source of active ingredients compared to the rhizomes.
关键词Paris polyphylla var. yunnanensis Rhizoma Paridis Steroidal saponins Sustainable utilization
资助信息National Natural Science Foundation of China; Natural Science Foundation of Yunnan Province; Science and Technology Research Program of Kunming Institute of Botany; Guiding Program of Interdisciplinary Studies from Kunming Institute of Botany, CAS; State Key Laboratory of Phytochemistry and Plant Resources in West China
DOI10.1016/j.jep.2018.05.028
语种英语
资助项目National Natural Science Foundation of China[31570363] ; National Natural Science Foundation of China[31770391] ; Natural Science Foundation of Yunnan Province[2015FA031] ; Science and Technology Research Program of Kunming Institute of Botany[KIB2016001] ; Guiding Program of Interdisciplinary Studies from Kunming Institute of Botany, CAS[KIB2017004] ; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2017-ZZ04]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS类目Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000442333900014
出版者ELSEVIER IRELAND LTD
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62064
专题中国科学院昆明植物研究所
通讯作者Liu, Hai-Yang
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Qin, Xu-Jie,Ni, Wei,Chen, Chang-Xiang,et al. Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis[J]. JOURNAL OF ETHNOPHARMACOLOGY,2018,224:134-139.
APA Qin, Xu-Jie,Ni, Wei,Chen, Chang-Xiang,&Liu, Hai-Yang.(2018).Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis.JOURNAL OF ETHNOPHARMACOLOGY,224,134-139.
MLA Qin, Xu-Jie,et al."Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis".JOURNAL OF ETHNOPHARMACOLOGY 224(2018):134-139.
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