Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum

doi:10.1021/acs.jnatprod.8b00110

	Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum
	Wang, Wenjing 1; Gong, Jiaojiao 1; Liu, Xiaorui 1; Dai, Chong 1; Wang, Yanyan 2,3; Li, Xiao-Nian 4; Wang, Jianping 1; Luo, Zengwei 1; Zhou, Yuan1 ; Xue, Yongbo 1; Zhu, Hucheng 1; Chen, Chunmei 1; Zhang, Yonghui 1
	2018-07-01
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
Volume	81 Issue:7 Pages:1578-1587
Abstract	The cocultivation of Aspergillus flavipes and Chaetomium globosum, rich sources of cytochalasans, on solid rice medium, resulted in the production of 13 new, highly oxygenated cytochalasans, aspochalasinols A-D (1-4) and oxichaetoglobosins A-I (5-13), as well as seven known compounds (14-20). Of these compounds, 13 is a novel cytochalasan with an unexpected 2-norindole group. The isolated compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Compounds 1-4 represent the first examples of Asp-type cytochalasans with C-12 hydroxy groups, which may be a result of the coculture, as hydroxylated Me-12 groups are frequently found in Chae-type cytochalasans from C. globosum. In addition, 5-10 are unusual cytochalasans with an oxygenated C-10. Interestingly, 13 is the first example of a naturally occurring cytochalasan possessing a uniquely degraded indole ring that is derived from chaetoglobosin W, with 11 and 12 both serving as its biosynthetic intermediates. In the coculture of A. flavipes and C. globosum, most of these cytochalasans are more functionalized than normal cytochalasans, and the underlying causes may attract substantial attention from synthetic biologists. The cytotoxicities against five human cancer cell lines (SW480, HL-60, A549, MCF-7, and SMMC-7721) and the immunomodulatory activities of these new compounds were evaluated in vitro.
DOI	10.1021/acs.jnatprod.8b00110
Language	英语
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/61687
Collection	植物化学与西部植物资源持续利用国家重点实验室
Affiliation	1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang 443003, Peoples R China 3.Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Wang, Wenjing,Gong, Jiaojiao,Liu, Xiaorui,et al. Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(7):1578-1587.
APA	Wang, Wenjing.,Gong, Jiaojiao.,Liu, Xiaorui.,Dai, Chong.,Wang, Yanyan.,...&Zhang, Yonghui.(2018).Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum.JOURNAL OF NATURAL PRODUCTS,81(7),1578-1587.
MLA	Wang, Wenjing,et al."Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum".JOURNAL OF NATURAL PRODUCTS 81.7(2018):1578-1587.

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