Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum

doi:10.1021/acs.jnatprod.8b00110

	Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum
	Wang, Wenjing 1; Gong, Jiaojiao 1; Liu, Xiaorui 1; Dai, Chong 1; Wang, Yanyan 2,3; Li, Xiao-Nian 4; Wang, Jianping 1; Luo, Zengwei 1; Zhou, Yuan1 ; Xue, Yongbo 1; Zhu, Hucheng 1; Chen, Chunmei 1; Zhang, Yonghui 1
	2018-07-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:7 页码:1578-1587
摘要	The cocultivation of Aspergillus flavipes and Chaetomium globosum, rich sources of cytochalasans, on solid rice medium, resulted in the production of 13 new, highly oxygenated cytochalasans, aspochalasinols A-D (1-4) and oxichaetoglobosins A-I (5-13), as well as seven known compounds (14-20). Of these compounds, 13 is a novel cytochalasan with an unexpected 2-norindole group. The isolated compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Compounds 1-4 represent the first examples of Asp-type cytochalasans with C-12 hydroxy groups, which may be a result of the coculture, as hydroxylated Me-12 groups are frequently found in Chae-type cytochalasans from C. globosum. In addition, 5-10 are unusual cytochalasans with an oxygenated C-10. Interestingly, 13 is the first example of a naturally occurring cytochalasan possessing a uniquely degraded indole ring that is derived from chaetoglobosin W, with 11 and 12 both serving as its biosynthetic intermediates. In the coculture of A. flavipes and C. globosum, most of these cytochalasans are more functionalized than normal cytochalasans, and the underlying causes may attract substantial attention from synthetic biologists. The cytotoxicities against five human cancer cell lines (SW480, HL-60, A549, MCF-7, and SMMC-7721) and the immunomodulatory activities of these new compounds were evaluated in vitro.
DOI	10.1021/acs.jnatprod.8b00110
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/61687
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang 443003, Peoples R China 3.Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wenjing,Gong, Jiaojiao,Liu, Xiaorui,et al. Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(7):1578-1587.
APA	Wang, Wenjing.,Gong, Jiaojiao.,Liu, Xiaorui.,Dai, Chong.,Wang, Yanyan.,...&Zhang, Yonghui.(2018).Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum.JOURNAL OF NATURAL PRODUCTS,81(7),1578-1587.
MLA	Wang, Wenjing,et al."Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum".JOURNAL OF NATURAL PRODUCTS 81.7(2018):1578-1587.