Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum
Wang, Wenjing1; Gong, Jiaojiao1; Liu, Xiaorui1; Dai, Chong1; Wang, Yanyan2,3; Li, Xiao-Nian4; Wang, Jianping1; Luo, Zengwei1; Zhou, Yuan1; Xue, Yongbo1; Zhu, Hucheng1; Chen, Chunmei1; Zhang, Yonghui1
2018-07-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:7页码:1578-1587
摘要The cocultivation of Aspergillus flavipes and Chaetomium globosum, rich sources of cytochalasans, on solid rice medium, resulted in the production of 13 new, highly oxygenated cytochalasans, aspochalasinols A-D (1-4) and oxichaetoglobosins A-I (5-13), as well as seven known compounds (14-20). Of these compounds, 13 is a novel cytochalasan with an unexpected 2-norindole group. The isolated compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Compounds 1-4 represent the first examples of Asp-type cytochalasans with C-12 hydroxy groups, which may be a result of the coculture, as hydroxylated Me-12 groups are frequently found in Chae-type cytochalasans from C. globosum. In addition, 5-10 are unusual cytochalasans with an oxygenated C-10. Interestingly, 13 is the first example of a naturally occurring cytochalasan possessing a uniquely degraded indole ring that is derived from chaetoglobosin W, with 11 and 12 both serving as its biosynthetic intermediates. In the coculture of A. flavipes and C. globosum, most of these cytochalasans are more functionalized than normal cytochalasans, and the underlying causes may attract substantial attention from synthetic biologists. The cytotoxicities against five human cancer cell lines (SW480, HL-60, A549, MCF-7, and SMMC-7721) and the immunomodulatory activities of these new compounds were evaluated in vitro.
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61687
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang 443003, Peoples R China
3.Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Wang, Wenjing,Gong, Jiaojiao,Liu, Xiaorui,et al. Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(7):1578-1587.
APA Wang, Wenjing.,Gong, Jiaojiao.,Liu, Xiaorui.,Dai, Chong.,Wang, Yanyan.,...&Zhang, Yonghui.(2018).Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum.JOURNAL OF NATURAL PRODUCTS,81(7),1578-1587.
MLA Wang, Wenjing,et al."Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum".JOURNAL OF NATURAL PRODUCTS 81.7(2018):1578-1587.
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