Structurally diverse diterpenoids from Isodon pharicus
Hu, Zheng-Xi1,2; Xu, Hou-Chao1; Hu, Kun1; Liu, Miao1; Li, Xiao-Nian1; Li, Xing-Ren1; Du, Xue1; Zhang, Yong-Hui2; Puno, Pema-Tenzin1; Sun, Han-Dong1
AbstractTwenty-one diterpenoids with diverse structures, including twelve new compounds (1-12), were isolated from the aerial parts of Isodon pharicus. Structurally, pharicusin A (1), composed of a benzoyl group coupled to a 7 alpha,20-epoxy-ent-kauranoid, represents an unprecedented C-27 meroditerpenoid; pharicusin B (2) is a novel trinorditerpenoid with an unreported 15,16,17-trinor-7 alpha,20-epoxy-ent-kaurane skeleton; pharicusin C (4) represents the first example of 7 alpha,20-epoxy-ent-atisane diterpenoids. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 2 and 3 were further confirmed by single-crystal X-ray diffraction and computational analysis of the optical rotatory dispersion (ORD). Selected sixteen isolates were evaluated for their in vitro cytotoxicity against a small panel of human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and compounds 9, 10, 13, 16, and 18 exhibited significant inhibitory effects against all five cell lines, with IC50 values in the range of 0.37-6.03 mu M.
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Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
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Hu, Zheng-Xi,Xu, Hou-Chao,Hu, Kun,et al. Structurally diverse diterpenoids from Isodon pharicus[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(15):2379-2389.
APA Hu, Zheng-Xi.,Xu, Hou-Chao.,Hu, Kun.,Liu, Miao.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2018).Structurally diverse diterpenoids from Isodon pharicus.ORGANIC CHEMISTRY FRONTIERS,5(15),2379-2389.
MLA Hu, Zheng-Xi,et al."Structurally diverse diterpenoids from Isodon pharicus".ORGANIC CHEMISTRY FRONTIERS 5.15(2018):2379-2389.
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