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题名: A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1
作者: Yang, Beiye1; Sun, Weiguang1; Wang, Jianping1; Lin, Shuang1; Li, Xiao-Nian2; Zhu, Hucheng1; Luo, Zengwei1; Xue, Yongbo1; Hu, Zhengxi1; Zhang, Yonghui1
刊名: MARINE DRUGS
关键词: marine-derived fungi ; Penicillium sp TJ403-1 ; breviane spiroditerpenoid ; IDH1 inhibitory activity ; cytotoxicity
英文摘要: Marine-derived fungi are a promising and untapped reservoir for discovering structurally interesting and pharmacologically active natural products. In our efforts to identify novel bioactive compounds from marine-derived fungi, four breviane spiroditerpenoids, including a new compound, brevione O (1), and three known compounds breviones I (2), J (3), and H (4), together with a known diketopiperazine alkaloid brevicompanine G (5), were isolated and identified from an ethyl acetate extract of the fermented rice substrate of the coral-derived fungus Penicillium sp. TJ403-1. The absolute structure of 1 was elucidated by HRESIMS, one-and two-dimensional NMR spectroscopic data, and a comparison of its electronic circular dichroism (ECD) spectrum with the literature. Moreover, we confirmed the absolute configuration of 5 by single-crystal X-ray crystallography. All the isolated compounds were evaluated for isocitrate dehydrogenase 1 (IDH1) inhibitory activity and cytotoxicity, and compound 2 showed significant inhibitory activities against HL-60, A-549, and HEP3B tumor cell lines with IC50 values of 4.92 +/- 0.65, 8.60 +/- 1.36, and 5.50 +/- 0.67 mu M, respectively.
出版日期: 2018-04-01
卷号: 16, 期号:4, 页码:110
DOI标识: 10.3390/md16040110
语种: 英语
ISSN号: 1660-3397
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/61240
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Yang, Beiye,Sun, Weiguang,Wang, Jianping,et al. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1[J]. MARINE DRUGS,2018,16(4):110.
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