A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1
Yang, Beiye1; Sun, Weiguang1; Wang, Jianping1; Lin, Shuang1; Li, Xiao-Nian2; Zhu, Hucheng1; Luo, Zengwei1; Xue, Yongbo1; Hu, Zhengxi1; Zhang, Yonghui1
2018-04-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号16期号:4页码:110
摘要Marine-derived fungi are a promising and untapped reservoir for discovering structurally interesting and pharmacologically active natural products. In our efforts to identify novel bioactive compounds from marine-derived fungi, four breviane spiroditerpenoids, including a new compound, brevione O (1), and three known compounds breviones I (2), J (3), and H (4), together with a known diketopiperazine alkaloid brevicompanine G (5), were isolated and identified from an ethyl acetate extract of the fermented rice substrate of the coral-derived fungus Penicillium sp. TJ403-1. The absolute structure of 1 was elucidated by HRESIMS, one-and two-dimensional NMR spectroscopic data, and a comparison of its electronic circular dichroism (ECD) spectrum with the literature. Moreover, we confirmed the absolute configuration of 5 by single-crystal X-ray crystallography. All the isolated compounds were evaluated for isocitrate dehydrogenase 1 (IDH1) inhibitory activity and cytotoxicity, and compound 2 showed significant inhibitory activities against HL-60, A-549, and HEP3B tumor cell lines with IC50 values of 4.92 +/- 0.65, 8.60 +/- 1.36, and 5.50 +/- 0.67 mu M, respectively.
关键词Marine-derived Fungi Penicillium Sp Tj403-1 Breviane Spiroditerpenoid Idh1 Inhibitory Activity Cytotoxicity
DOI10.3390/md16040110
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61240
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Yang, Beiye,Sun, Weiguang,Wang, Jianping,et al. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1[J]. MARINE DRUGS,2018,16(4):110.
APA Yang, Beiye.,Sun, Weiguang.,Wang, Jianping.,Lin, Shuang.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2018).A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1.MARINE DRUGS,16(4),110.
MLA Yang, Beiye,et al."A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1".MARINE DRUGS 16.4(2018):110.
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