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题名: Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus
作者: Qi, Yan-Yan1, 2; Su, Jia1; Zhang, Zhi-Jun1, 2; Li, Lai-Wei1, 2; Fan, Min1, 2; Zhu, Yu1, 2; Wu, Xing-De1; Zhao, Qin-Shi1
刊名: CHEMISTRY & BIODIVERSITY
关键词: Podocarpus macrophyllus ; norditerpenoid ; anti-proliferative activity ; activity-guided fractionation ; structure revision
英文摘要: Activity-guided fractionation strategy was used to investigate chemical constituents from the roots of Podocarpus macrophyllus. Successfully, two new norditerpenes, 2-hydroxymakilactone A (1) and 3-hydroxymakilactone A (2), along with ten known analogues (3-12) were isolated. The structures of 1 and 2 were elucidated by spectroscopic analysis including 1D-, 2D-NMR, and HR-ESI-MS data. The previously reported structure of 2,3-dihydro-2-hydroxypodolide was revised as 2,3-dihydro-2-hydroxypodolide (3) by spectroscopic analysis, and was further confirmed by X-ray crystallographic analysis. Cytotoxic activities of all isolated compounds against five human solid tumour cell lines (AGS, HeLa, MDA-MB-231, HepG-2, and PANC-1) were evaluated. All of them exhibited anti-proliferative activities (IC50=0.3-27m), except for 10. Compounds 1, 4, 5, 6, and 8 exhibited potent inhibitory activities with IC50<1m against HeLa and AGS cells.
出版日期: 2018-04-01
卷号: 15, 期号:4
DOI标识: 10.1002/cbdv.201800043
语种: 英语
ISSN号: 1612-1872
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/61235
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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