Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus
Qi, Yan-Yan1,2; Su, Jia1; Zhang, Zhi-Jun1,2; Li, Lai-Wei1,2; Fan, Min1,2; Zhu, Yu1,2; Wu, Xing-De1; Zhao, Qin-Shi1
2018-04-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号15期号:4
摘要Activity-guided fractionation strategy was used to investigate chemical constituents from the roots of Podocarpus macrophyllus. Successfully, two new norditerpenes, 2-hydroxymakilactone A (1) and 3-hydroxymakilactone A (2), along with ten known analogues (3-12) were isolated. The structures of 1 and 2 were elucidated by spectroscopic analysis including 1D-, 2D-NMR, and HR-ESI-MS data. The previously reported structure of 2,3-dihydro-2-hydroxypodolide was revised as 2,3-dihydro-2-hydroxypodolide (3) by spectroscopic analysis, and was further confirmed by X-ray crystallographic analysis. Cytotoxic activities of all isolated compounds against five human solid tumour cell lines (AGS, HeLa, MDA-MB-231, HepG-2, and PANC-1) were evaluated. All of them exhibited anti-proliferative activities (IC50=0.3-27m), except for 10. Compounds 1, 4, 5, 6, and 8 exhibited potent inhibitory activities with IC50<1m against HeLa and AGS cells.
关键词Podocarpus Macrophyllus Norditerpenoid Anti-proliferative Activity Activity-guided Fractionation Structure Revision
DOI10.1002/cbdv.201800043
语种英语
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61235
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Qi, Yan-Yan,Su, Jia,Zhang, Zhi-Jun,et al. Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus[J]. CHEMISTRY & BIODIVERSITY,2018,15(4).
APA Qi, Yan-Yan.,Su, Jia.,Zhang, Zhi-Jun.,Li, Lai-Wei.,Fan, Min.,...&Zhao, Qin-Shi.(2018).Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus.CHEMISTRY & BIODIVERSITY,15(4).
MLA Qi, Yan-Yan,et al."Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus".CHEMISTRY & BIODIVERSITY 15.4(2018).
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