New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia
Fan, Min1,2,3; Bao, Ying1,2,3; Zhang, Zhi-Jun2,3; Zhang, Hong-Bin1; Zhao, Qin-Shi2
2017-11-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号123页码:44-50
摘要Five new neo-clerodane diterpenoids, tiliifolins A-E (1-5), along with ten known ones, were isolated from the aerial part of Salvia tiliifolia. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. All new compounds were evaluated for their neurotrophic activity on PC12 cells and cytotoxicity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480), and compound 5 showed statistically significant neuroprotective effect in vitro assay.
关键词Salvia Tiliifolia Neo-clerodane Diterpenoids Neurotrophic Activities Cytotoxicity
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60608
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resources, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Fan, Min,Bao, Ying,Zhang, Zhi-Jun,et al. New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia[J]. FITOTERAPIA,2017,123:44-50.
APA Fan, Min,Bao, Ying,Zhang, Zhi-Jun,Zhang, Hong-Bin,&Zhao, Qin-Shi.(2017).New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia.FITOTERAPIA,123,44-50.
MLA Fan, Min,et al."New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia".FITOTERAPIA 123(2017):44-50.
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