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题名: 7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus
作者: Hu, Zheng-Xi1, 2; Liu, Miao1; Wang, Wei-Guang1; Li, Xiao-Nian1; Hu, Kun1; Li, Xing-Ren1; Du, Xue1; Zhang, Yong-Hui2; Puno, Pema-Tenzin1; Sun, Han-Dong1
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: A phytochemical investigation of an ethyl acetate extract of the aerial parts of Isodon pharicus led to the isolation of 21 new 7 alpha,20-epoxy-ent-kaurane diterpenoids, pharicins C-W (1-21), and 29 known (22-50) analogues. The structural characterization of 1-21 and assignment of their relative configurations were accomplished by spectroscopic data interpretation, while the structures of 1 and 16 were confirmed by X-ray crystallography. The absolute stereostructure of 1 was confirmed by electronic circular dichroism data analysis. Twenty-five of the diterpenoids were screened for their cytotoxic activities against a panel of tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compounds 11, 16, 38, and 48 exhibited inhibitory activities against these tumor cell lines with IC50 values ranging from 1.01 to 9.62 mu M, while 2, 15, 29, and 47 exhibited moderate cytotoxic potency.
出版日期: 2018
卷号: 81, 期号:1, 页码:106-116
DOI标识: 10.1021/acs.jnatprod.7b00723
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/60579
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
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