7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus
Hu, Zheng-Xi1,2; Liu, Miao1; Wang, Wei-Guang1; Li, Xiao-Nian1; Hu, Kun1; Li, Xing-Ren1; Du, Xue1; Zhang, Yong-Hui2; Puno, Pema-Tenzin1; Sun, Han-Dong1
2018
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:1页码:106-116
摘要A phytochemical investigation of an ethyl acetate extract of the aerial parts of Isodon pharicus led to the isolation of 21 new 7 alpha,20-epoxy-ent-kaurane diterpenoids, pharicins C-W (1-21), and 29 known (22-50) analogues. The structural characterization of 1-21 and assignment of their relative configurations were accomplished by spectroscopic data interpretation, while the structures of 1 and 16 were confirmed by X-ray crystallography. The absolute stereostructure of 1 was confirmed by electronic circular dichroism data analysis. Twenty-five of the diterpenoids were screened for their cytotoxic activities against a panel of tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compounds 11, 16, 38, and 48 exhibited inhibitory activities against these tumor cell lines with IC50 values ranging from 1.01 to 9.62 mu M, while 2, 15, 29, and 47 exhibited moderate cytotoxic potency.
DOI10.1021/acs.jnatprod.7b00723
语种英语
WOS记录号WOS:000423778900016
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60579
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
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Hu, Zheng-Xi,Liu, Miao,Wang, Wei-Guang,et al. 7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(1):106-116.
APA Hu, Zheng-Xi.,Liu, Miao.,Wang, Wei-Guang.,Li, Xiao-Nian.,Hu, Kun.,...&Sun, Han-Dong.(2018).7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus.JOURNAL OF NATURAL PRODUCTS,81(1),106-116.
MLA Hu, Zheng-Xi,et al."7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus".JOURNAL OF NATURAL PRODUCTS 81.1(2018):106-116.
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