Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi

doi:10.1021/acs.jafc.7b04998

	Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi
	Huang, Rong 2; Jiang, Bo-Guang 1; Li, Xiao-Nian 3; Wang, Ya-Ting 1; Liu, Si-Si 1; Zheng, Kai-Xuan 1; He, Jian 4; Wu, Shao-Hua 1
	2018-02-07
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	66 期号:5 页码:1140-1146
摘要	Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising a-glycosidase inhibitory activity with IC50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC50 = 1.22 mM).
关键词	Phomopsis Paeonia Delavayi Polyoxygenated Cyclohexenoids Alpha-glucosidase Inhibitor
DOI	10.1021/acs.jafc.7b04998
语种	英语
WOS记录号	WOS:000424851900011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60563
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Yunnan Inst Microbiol, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Huang, Rong,Jiang, Bo-Guang,Li, Xiao-Nian,et al. Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(5):1140-1146.
APA	Huang, Rong.,Jiang, Bo-Guang.,Li, Xiao-Nian.,Wang, Ya-Ting.,Liu, Si-Si.,...&Wu, Shao-Hua.(2018).Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(5),1140-1146.
MLA	Huang, Rong,et al."Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.5(2018):1140-1146.