Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi
Huang, Rong2; Jiang, Bo-Guang1; Li, Xiao-Nian3; Wang, Ya-Ting1; Liu, Si-Si1; Zheng, Kai-Xuan1; He, Jian4; Wu, Shao-Hua1
2018-02-07
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号66页码:1140-1146
摘要Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising a-glycosidase inhibitory activity with IC50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC50 = 1.22 mM).
关键词Phomopsis Paeonia Delavayi Polyoxygenated Cyclohexenoids Alpha-glucosidase Inhibitor
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60563
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Yunnan Inst Microbiol, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, Guangzhou 510515, Guangdong, Peoples R China
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Huang, Rong,Jiang, Bo-Guang,Li, Xiao-Nian,et al. Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(5):1140-1146.
APA Huang, Rong.,Jiang, Bo-Guang.,Li, Xiao-Nian.,Wang, Ya-Ting.,Liu, Si-Si.,...&Wu, Shao-Hua.(2018).Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(5),1140-1146.
MLA Huang, Rong,et al."Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.5(2018):1140-1146.
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