Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions
Zhao, Longyan1,2; Qin, Yujing1; Guan, Ruowei1; Zheng, Wenqi1; Liu, Jikai1,2; Zhao, Jinhua1,2,3
2018-04-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume186Pages:217-225
AbstractThe digestibility of fucosylated glycosaminoglycan (FG) and its effects on digestive enzymes were investigated using an in vitro digestion model. Results showed that the molecular weight and the reducing sugar content of FG were not significantly changed, and no free monosaccharides released from FG were detected after the salivary, gastric and intestinal digestion, indicating that both the backbone and the sulfated fucose branches of FG are resistant to be cleaved in the saliva and gastrointestinal tract environments. Furthermore, FG can dose-dependently inhibit digestive enzymes such as alpha-amylase, pepsin and pancreatic lipase in different degrees under the simulated digestion conditions due to the sulfate and carboxyl groups. These physiological effects of FG may help control the postprandial glucose concentration and have the potential in the prevention or treatment of reflux disease and obesity. The findings may provide information on the digestibility and beneficial physiological effects of FG as a potential natural product to promote human health.
KeywordSea Cucumber Polysaccharide Fucosylated Glycosaminoglycan In Vitro Digestion Digestive Enzyme
DOI10.1016/j.carbpol.2018.01.029
Language英语
WOS IDWOS:000426360800025
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60538
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.South Cent Univ Nationalities, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan 430074, Hubei, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Longyan,Qin, Yujing,Guan, Ruowei,et al. Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions[J]. CARBOHYDRATE POLYMERS,2018,186:217-225.
APA Zhao, Longyan,Qin, Yujing,Guan, Ruowei,Zheng, Wenqi,Liu, Jikai,&Zhao, Jinhua.(2018).Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions.CARBOHYDRATE POLYMERS,186,217-225.
MLA Zhao, Longyan,et al."Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions".CARBOHYDRATE POLYMERS 186(2018):217-225.
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