Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions

doi:10.1016/j.carbpol.2018.01.029

	Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions
	Zhao, Longyan1,2 ; Qin, Yujing 1; Guan, Ruowei 1; Zheng, Wenqi 1; Liu, Jikai 1,2; Zhao, Jinhua1,2,3
	2018-04-15
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	186 页码:217-225
摘要	The digestibility of fucosylated glycosaminoglycan (FG) and its effects on digestive enzymes were investigated using an in vitro digestion model. Results showed that the molecular weight and the reducing sugar content of FG were not significantly changed, and no free monosaccharides released from FG were detected after the salivary, gastric and intestinal digestion, indicating that both the backbone and the sulfated fucose branches of FG are resistant to be cleaved in the saliva and gastrointestinal tract environments. Furthermore, FG can dose-dependently inhibit digestive enzymes such as alpha-amylase, pepsin and pancreatic lipase in different degrees under the simulated digestion conditions due to the sulfate and carboxyl groups. These physiological effects of FG may help control the postprandial glucose concentration and have the potential in the prevention or treatment of reflux disease and obesity. The findings may provide information on the digestibility and beneficial physiological effects of FG as a potential natural product to promote human health.
关键词	Sea Cucumber Polysaccharide Fucosylated Glycosaminoglycan In Vitro Digestion Digestive Enzyme
DOI	10.1016/j.carbpol.2018.01.029
语种	英语
WOS记录号	WOS:000426360800025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60538
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.South Cent Univ Nationalities, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan 430074, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Longyan,Qin, Yujing,Guan, Ruowei,et al. Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions[J]. CARBOHYDRATE POLYMERS,2018,186:217-225.
APA	Zhao, Longyan,Qin, Yujing,Guan, Ruowei,Zheng, Wenqi,Liu, Jikai,&Zhao, Jinhua.(2018).Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions.CARBOHYDRATE POLYMERS,186,217-225.
MLA	Zhao, Longyan,et al."Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions".CARBOHYDRATE POLYMERS 186(2018):217-225.