中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum
作者: Yang, Dan1, 2, 3, 4; Cheng, Zhong-Quan3; Yang, Liu1, 2; Hou, Bo1, 2; Yang, Jin1, 2; Li, Xiao-Nian1, 2; Zi, Cheng-Ting1, 2, 4; Dong, Fa-Wu1, 2; Liu, Zheng-Hua1, 2; Zhou, Jun1, 2; Ding, Zhong-Tao4; Hu, Jiang-Miao1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Investigation of the 95% EtOH extract of stems of Dendrobium findlayanum afforded four new seco-dendrobines, findlayines A-D (1-4); two known dendrobines, dendrobine (5) and 2-hydroxydendrobine (6); and four new phenolic compounds, dendrofindlaphenols A-C (7, 9, and 10) and 6 ''-de-O-rnethyldendrofindlaphenol A (8). Compounds 1 and 2 are the first seco-dendrobines possessing a seven membered lactam moiety, with 3 and 4 derived from the oxidative cleavage of the C-2-C-3 bond of dendrobine. The structures were established using spectroscopic methods and by comparison with literature data. The absolute configurations of 1-4 were confirmed via single-crystal X-ray diffraction data. Cytotoxic activity assays against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines revealed IC50 values ranging from 2.3 to 5.3 mu M for compound 7, from 19.4 to 34.4 mu M for 8, and from 49.4 to 96.8 mu g/mL for the EtOAc extract. An assay of the inhibition of NO production with RAW 264.7 cells indicated that 8 had an IC50 value of 21.4 mu M, and the EtOAc extract, 10.5 mu g/mL. The EtOAc extract possessed DPPH radical scavenging activity of 69.93% at 100 mu g/mL.
出版日期: 2018-02-01
卷号: 81, 期号:2, 页码:227-235
DOI标识: 10.1021/acs.jnatprod.7b00150
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/60535
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
acs.jnatprod.7b00150.pdf(2040KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Guilin Normal Coll, Guilin 541001, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China

Recommended Citation:
Yang, Dan,Cheng, Zhong-Quan,Yang, Liu,et al. Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):227-235.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Dan]'s Articles
[Cheng, Zhong-Quan]'s Articles
[Yang, Liu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Dan]‘s Articles
[Cheng, Zhong-Quan]‘s Articles
[Yang, Liu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: acs.jnatprod.7b00150.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院昆明植物研究所 - Feedback
Powered by CSpace