Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum
Yang, Dan1,2,3,4; Cheng, Zhong-Quan3; Yang, Liu1,2; Hou, Bo1,2; Yang, Jin1,2; Li, Xiao-Nian1,2; Zi, Cheng-Ting1,2,4; Dong, Fa-Wu1,2; Liu, Zheng-Hua1,2; Zhou, Jun1,2; Ding, Zhong-Tao4; Hu, Jiang-Miao1,2
2018-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:2页码:227-235
摘要Investigation of the 95% EtOH extract of stems of Dendrobium findlayanum afforded four new seco-dendrobines, findlayines A-D (1-4); two known dendrobines, dendrobine (5) and 2-hydroxydendrobine (6); and four new phenolic compounds, dendrofindlaphenols A-C (7, 9, and 10) and 6 ''-de-O-rnethyldendrofindlaphenol A (8). Compounds 1 and 2 are the first seco-dendrobines possessing a seven membered lactam moiety, with 3 and 4 derived from the oxidative cleavage of the C-2-C-3 bond of dendrobine. The structures were established using spectroscopic methods and by comparison with literature data. The absolute configurations of 1-4 were confirmed via single-crystal X-ray diffraction data. Cytotoxic activity assays against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines revealed IC50 values ranging from 2.3 to 5.3 mu M for compound 7, from 19.4 to 34.4 mu M for 8, and from 49.4 to 96.8 mu g/mL for the EtOAc extract. An assay of the inhibition of NO production with RAW 264.7 cells indicated that 8 had an IC50 value of 21.4 mu M, and the EtOAc extract, 10.5 mu g/mL. The EtOAc extract possessed DPPH radical scavenging activity of 69.93% at 100 mu g/mL.
DOI10.1021/acs.jnatprod.7b00150
语种英语
WOS记录号WOS:000426618300002
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60535
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Guilin Normal Coll, Guilin 541001, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
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Yang, Dan,Cheng, Zhong-Quan,Yang, Liu,et al. Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):227-235.
APA Yang, Dan.,Cheng, Zhong-Quan.,Yang, Liu.,Hou, Bo.,Yang, Jin.,...&Hu, Jiang-Miao.(2018).Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum.JOURNAL OF NATURAL PRODUCTS,81(2),227-235.
MLA Yang, Dan,et al."Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum".JOURNAL OF NATURAL PRODUCTS 81.2(2018):227-235.
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