Pheophytin analogues from the medicinal lichen Usnea diffracta
Xu, Hong-Bo1; Yang, Tong-Hua2; Xie, Pei1; Liu, Shi-Jun1; Liang, Yan-Ni1; Zhang, Yu1; Song, Zhong-Xing1; Tang, Zhi-Shu1
2018
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
卷号32期号:9页码:1088-1094
摘要A new pheophytin, (13(2)S, 17S, 18S)-13(2)-hydroxy-20-chloro-ethylpheophorbide a (3), along with two known analogues (1-2) were isolated from the lichen Usnea diffracta Vainio (Parmeliaceae). Among them, compound 3 was a rare C-20-chloro type pheophytin obtained from lichens. Their structures were elucidated by extensive spectroscopic analysis, and all the compounds were obtained for the first time from U. diffracta. Compounds (1-3) were evaluated for their xanthine oxidase (XO) inhibitory activities in vitro, and the results showed that 1-3 possessed significant enzyme inhibitory actions with IC50 values of 46.9 +/- 3.8, 75.9 +/- 7.4 and 42.1 +/- 1.7g/mL, respectively.
关键词Usnea Diffracta Pheophytin Xanthine Oxidase
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60533
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Shaanxi Univ Chinese Med, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Shaanxi Prov Key Lab New Drugs & Chinese Med Fdn, Xianyang, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
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Xu, Hong-Bo,Yang, Tong-Hua,Xie, Pei,et al. Pheophytin analogues from the medicinal lichen Usnea diffracta[J]. NATURAL PRODUCT RESEARCH,2018,32(9):1088-1094.
APA Xu, Hong-Bo.,Yang, Tong-Hua.,Xie, Pei.,Liu, Shi-Jun.,Liang, Yan-Ni.,...&Tang, Zhi-Shu.(2018).Pheophytin analogues from the medicinal lichen Usnea diffracta.NATURAL PRODUCT RESEARCH,32(9),1088-1094.
MLA Xu, Hong-Bo,et al."Pheophytin analogues from the medicinal lichen Usnea diffracta".NATURAL PRODUCT RESEARCH 32.9(2018):1088-1094.
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