Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi

doi:10.1016/j.phytochem.2018.01.013

	Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi
	Zheng, Guowei 1,2; Luo, Shihong 1,3; Li, Shifei 4; Hua, Juan 1; Li, Weiqi2 ; Li, Shenghong1
	2018-04-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	148 页码:57-62
摘要	The Asteraceae plant Ageratina adenophora (also called Eupatorium adenophorum) has became the most destructive invasive species in China, especially the southwestern region, and is gravely threatening the native biodiversity. Its high reproductive capacity is partly due to the developed root system. From the roots of A. adenophora, ten compounds including three previously undescribed benzofuran derivatives (7-hydroxy-dehydrotremetone, 7,10,11-trihydroxy dehydrotremetone, 10-oxo-7-hydroxy-nordehydro-tremetone), a previously undescribed chromene derivative (5-beta-glucosyl-7-demethoxy-encecalin) and a previously undescribed monoterpene glucoside (8-hydroxy-8-beta-glucosy1-2-carene) were isolated and identified. The previously undescribed structures were established by spectroscopic studies including 1 D and 2D-NMR and HR-MS analyses. Antifungal activity of six compounds against one strain of pathogenic fungus of A. adenophora, Alternaria alternata, and other four strains of agricultural pathogenic fungi, Colletotrichum gloeosporioides, C. musae, Rhizoctonia solani and Fusarium oxysporum f. sp. niveum were investigated. The most abundant compound we isolated from A. adenophora roots was 7-hydroxy-dehydrotremetone, which showed significant broad-spectral inhibitory activity against the growth of all tested fungal strains, with diameter of inhibitory zones ranging from 13.90 +/- 1.05 mm to 17.28 +/- 0.46 mm at 50 mu g/disk (nystatin: 24.76 +/- 1.19 mm to 36.64 +/- 0.85 mm). Encecalin also showed weak inhibitory activity against F oxysporum f. sp. niveum, while other compounds were not active. Our results suggested that 7-hydroxy-dehydrotremetone might function as a constitutive defense compound in the roots of A. adenophora against pathogenic fungi. (C) 2018 Elsevier Ltd. All rights reserved.
关键词	Ageratina Adenophora Asteraceae Roots Specialized Metabolites Antifungal Activity
DOI	10.1016/j.phytochem.2018.01.013
语种	英语
WOS记录号	WOS:000427334600007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60524
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Kunming 650201, Yunnan, Peoples R China 3.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Liaoning, Peoples R China 4.Shanxi Univ, Inst Mol Sci, Taiyuan 030006, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Guowei,Luo, Shihong,Li, Shifei,et al. Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi[J]. PHYTOCHEMISTRY,2018,148:57-62.
APA	Zheng, Guowei,Luo, Shihong,Li, Shifei,Hua, Juan,Li, Weiqi,&Li, Shenghong.(2018).Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi.PHYTOCHEMISTRY,148,57-62.
MLA	Zheng, Guowei,et al."Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi".PHYTOCHEMISTRY 148(2018):57-62.