Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens
Wang, Bei1,3; Yang, Zi-Feng2; Zhao, Yun-Li1; Liu, Ya-Ping1; Deng, Jun1; Huang, Wan-Yi2; Li, Xiao-Nian1; Wang, Xin-Hua2; Luo, Xiao-Dong1,2
2018-03-16
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume20Issue:6Pages:1647-1650
AbstractDactyllactone A (1), which was isolated from Dactylicapnos scandens, is an isoquinoline alkloid with a rearranged and reconstructed D ring, making it ithe first of a new subtype of aporphines. Compound 1 might be derived from a common aporphine skeleton, which may have undergone biogenetic rearrangement and cleavage of the aromatic ring. Its structure was determined by extensive spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited anti-inflammatory activity in vitro significantly by inhibiting the expression of IL-1 beta' and PGE2 in a dose-dependent manner.
DOI10.1021/acs.orglett.8b00400
Language英语
WOS IDWOS:000428003600041
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60521
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Bei,Yang, Zi-Feng,Zhao, Yun-Li,et al. Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens[J]. ORGANIC LETTERS,2018,20(6):1647-1650.
APA Wang, Bei.,Yang, Zi-Feng.,Zhao, Yun-Li.,Liu, Ya-Ping.,Deng, Jun.,...&Luo, Xiao-Dong.(2018).Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens.ORGANIC LETTERS,20(6),1647-1650.
MLA Wang, Bei,et al."Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens".ORGANIC LETTERS 20.6(2018):1647-1650.
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