| Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens | |
Wang, Bei1,3; Yang, Zi-Feng2; Zhao, Yun-Li1; Liu, Ya-Ping1; Deng, Jun1; Huang, Wan-Yi2; Li, Xiao-Nian1; Wang, Xin-Hua2; Luo, Xiao-Dong1,2
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| 2018-03-16 | |
| 发表期刊 | ORGANIC LETTERS
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| ISSN | 1523-7060 |
| 卷号 | 20期号:6页码:1647-1650 |
| 摘要 | Dactyllactone A (1), which was isolated from Dactylicapnos scandens, is an isoquinoline alkloid with a rearranged and reconstructed D ring, making it ithe first of a new subtype of aporphines. Compound 1 might be derived from a common aporphine skeleton, which may have undergone biogenetic rearrangement and cleavage of the aromatic ring. Its structure was determined by extensive spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited anti-inflammatory activity in vitro significantly by inhibiting the expression of IL-1 beta' and PGE2 in a dose-dependent manner. |
| DOI | 10.1021/acs.orglett.8b00400 |
| 语种 | 英语 |
| WOS记录号 | WOS:000428003600041 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/60521 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Bei,Yang, Zi-Feng,Zhao, Yun-Li,et al. Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens[J]. ORGANIC LETTERS,2018,20(6):1647-1650. |
| APA | Wang, Bei.,Yang, Zi-Feng.,Zhao, Yun-Li.,Liu, Ya-Ping.,Deng, Jun.,...&Luo, Xiao-Dong.(2018).Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens.ORGANIC LETTERS,20(6),1647-1650. |
| MLA | Wang, Bei,et al."Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens".ORGANIC LETTERS 20.6(2018):1647-1650. |
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| wang2018.pdf（1144KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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