Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens

doi:10.1021/acs.orglett.8b00400

	Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens
	Wang, Bei 1,3; Yang, Zi-Feng 2; Zhao, Yun-Li 1; Liu, Ya-Ping 1; Deng, Jun 1; Huang, Wan-Yi 2; Li, Xiao-Nian 1; Wang, Xin-Hua 2; Luo, Xiao-Dong1,2
	2018-03-16
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	20 期号:6 页码:1647-1650
摘要	Dactyllactone A (1), which was isolated from Dactylicapnos scandens, is an isoquinoline alkloid with a rearranged and reconstructed D ring, making it ithe first of a new subtype of aporphines. Compound 1 might be derived from a common aporphine skeleton, which may have undergone biogenetic rearrangement and cleavage of the aromatic ring. Its structure was determined by extensive spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited anti-inflammatory activity in vitro significantly by inhibiting the expression of IL-1 beta' and PGE2 in a dose-dependent manner.
DOI	10.1021/acs.orglett.8b00400
语种	英语
WOS记录号	WOS:000428003600041
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60521
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bei,Yang, Zi-Feng,Zhao, Yun-Li,et al. Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens[J]. ORGANIC LETTERS,2018,20(6):1647-1650.
APA	Wang, Bei.,Yang, Zi-Feng.,Zhao, Yun-Li.,Liu, Ya-Ping.,Deng, Jun.,...&Luo, Xiao-Dong.(2018).Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens.ORGANIC LETTERS,20(6),1647-1650.
MLA	Wang, Bei,et al."Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens".ORGANIC LETTERS 20.6(2018):1647-1650.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
wang2018.pdf（1144KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载