Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching | |
Zhang, Zhi-Jun1,2; Qi, Yan-Yan1,2; Wu, Xing-De1; Su, Jia1; Zhao, Qin-Shi1![]() | |
2018-04-05 | |
发表期刊 | TETRAHEDRON
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ISSN | 0040-4020 |
卷号 | 74期号:14页码:1692-1697 |
摘要 | Five new fawcettimine-type alkaloids (1-5) and three new natural products (6-8), along with four known analogues, fawcettimine (9), fewcettidine (10), lycopoclavamine B (11), and lycopladine B (12), were isolated from the whole plant of Lycopodium complanatum var. glaucum Ching. The structures of lycogladines A-H (1-8) were determined based on HRESIMS, 1D and 2D NMR spectroscopic analysis, as well as single-crystal X-ray diffraction. Compound 1 possesses a new ring system that is formed through the linkage of C-13-O-C-2, which is rarely present in Lycopodium alkaloids (LAs). Compounds 1-8 were tested for their beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACEI) and acetylcholinesterase (AChE) inhibitory activities. (C) 2018 Published by Elsevier Ltd. |
关键词 | Lycopodium Complanatum Var. Glaucum Ching Lycopodium Alkaloids Lycogladines A-h Anti-ache Activity Anti-bace1 Activity |
DOI | 10.1016/j.tet.2018.02.034 |
语种 | 英语 |
WOS记录号 | WOS:000428484000009 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/60513 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Zhi-Jun,Qi, Yan-Yan,Wu, Xing-De,et al. Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching[J]. TETRAHEDRON,2018,74(14):1692-1697. |
APA | Zhang, Zhi-Jun,Qi, Yan-Yan,Wu, Xing-De,Su, Jia,&Zhao, Qin-Shi.(2018).Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching.TETRAHEDRON,74(14),1692-1697. |
MLA | Zhang, Zhi-Jun,et al."Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching".TETRAHEDRON 74.14(2018):1692-1697. |
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