Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching
Zhang, Zhi-Jun1,2; Qi, Yan-Yan1,2; Wu, Xing-De1; Su, Jia1; Zhao, Qin-Shi1
2018-04-05
发表期刊TETRAHEDRON
ISSN0040-4020
卷号74页码:1692-1697
摘要Five new fawcettimine-type alkaloids (1-5) and three new natural products (6-8), along with four known analogues, fawcettimine (9), fewcettidine (10), lycopoclavamine B (11), and lycopladine B (12), were isolated from the whole plant of Lycopodium complanatum var. glaucum Ching. The structures of lycogladines A-H (1-8) were determined based on HRESIMS, 1D and 2D NMR spectroscopic analysis, as well as single-crystal X-ray diffraction. Compound 1 possesses a new ring system that is formed through the linkage of C-13-O-C-2, which is rarely present in Lycopodium alkaloids (LAs). Compounds 1-8 were tested for their beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACEI) and acetylcholinesterase (AChE) inhibitory activities. (C) 2018 Published by Elsevier Ltd.
关键词Lycopodium Complanatum Var. Glaucum Ching Lycopodium Alkaloids Lycogladines A-h Anti-ache Activity Anti-bace1 Activity
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60513
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Zhi-Jun,Qi, Yan-Yan,Wu, Xing-De,et al. Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching[J]. TETRAHEDRON,2018,74(14):1692-1697.
APA Zhang, Zhi-Jun,Qi, Yan-Yan,Wu, Xing-De,Su, Jia,&Zhao, Qin-Shi.(2018).Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching.TETRAHEDRON,74(14),1692-1697.
MLA Zhang, Zhi-Jun,et al."Ly1 cogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching".TETRAHEDRON 74.14(2018):1692-1697.
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