Novel Sodium Channel Inhibitor From Leeches
Wang, Gan1; Long, Chengbo1; Liu, Weihui1; Xu, Cheng1; Zhang, Min1,2; Li, Qiong3; Lu, Qiumin1,4; Meng, Ping1; Li, Dongsheng1; Rong, Mingqiang1; Sun, Zhaohui5; Luo, Xiaodong3; Lai, Ren1,6
2018-03-06
发表期刊FRONTIERS IN PHARMACOLOGY
ISSN1663-9812
卷号9页码:186
摘要Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function has been reported from leech saliva although clinical applications strongly indicated that leech therapy produces a strong and long lasting pain-reducing effect. Herein, a novel family of small peptides (HSTXs) including 11 members which show low similarity with known peptides was identified from salivary glands of the leech Haemadipsa sylvestris. A typical HSTX is composed of 22-25 amino acid residues including four half-cysteines, forming two intra-molecular disulfide bridges, and an amidated C-terminus. HSTX-I exerts significant analgesic function by specifically inhibiting voltage-gated sodium (Nay) channels (Nav1.8 and Nav1.9) which contribute to action potential electrogenesis in neurons and potential targets to develop analgesics. This study reveals that sodium channel inhibitors are analgesic substances in the leech. HSTXs are excellent candidates or templates for development of analgesics.
关键词Leech Therapy Blood-sucking Sodium Channel Pain Analgesia
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60445
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptides Yunnan Prov, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Chinese Acad Sci, Sino African Joint Res Ctr, Wuhan, Hubei, Peoples R China
5.Guangzhou Gen Hosp Guangzhou Mil Command PLA, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China
6.Nanjing Agr Univ, Life Sci Coll, Nanjing, Jiangsu, Peoples R China
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Wang, Gan,Long, Chengbo,Liu, Weihui,et al. Novel Sodium Channel Inhibitor From Leeches[J]. FRONTIERS IN PHARMACOLOGY,2018,9:186.
APA Wang, Gan.,Long, Chengbo.,Liu, Weihui.,Xu, Cheng.,Zhang, Min.,...&Lai, Ren.(2018).Novel Sodium Channel Inhibitor From Leeches.FRONTIERS IN PHARMACOLOGY,9,186.
MLA Wang, Gan,et al."Novel Sodium Channel Inhibitor From Leeches".FRONTIERS IN PHARMACOLOGY 9(2018):186.
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