| Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni | |
Li, Xiaomei1,2; Luo, Lan1; Cai, Ying1,2; Yang, Wenjiao1,2; Lin, Lisha1; Li, Zi1; Gao, Na1; Purcell, Steven W.3; Wu, Mingyi1; Zhao, Jinhua1
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| 2017-10-25 | |
| 发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| ISSN | 0021-8561 |
| 卷号 | 65期号:42页码:9315-9323 |
| 摘要 | Edible sea cucumbers are widely used as a health food and medicine. A fucosylated glycosaminoglycan (FG) was purified from the high-value sea cucumber Stichopus herrmanni. Its physicochemical properties and structure were analyzed and characterized by chemical and instrumental methods: Chemical analysis indicated that this FG with a molecular weight of similar to 64 kDa is composed of N-acetyl-D-galactosamin D-glucuronic acid (GlcA), and L-fucose. Structural analysis clarified that the FG contains the chondroitin sulfate E-like backbone, with-mostly 2,4-di-O-sulfated (85%) and some 3,4-di-O-sulfated (10%) and 4-O-sulfated (5%) fucose side chains that link to the C3 position of GlcA. This FG is structurally highly regular and homogeneous, differing from the FGs of other sea cucumbers, for its sulfation'patterns, are simpler. Biological activity assays indicated that it is a strong anticoagulant, inhibiting thrombin and intrinsic factor Xase. Out results expand the knowledge on structural types of FG and illustrate its biological activity as a functional food material. |
| 关键词 | Sea Cucumber Fucosylated Glycosaminoglycan Chemical Structure Anticoagulant Stiehopus Herrmanni |
| DOI | 10.1021/acs.jafc.7b03867 |
| 语种 | 英语 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/60346 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Southern Cross Univ, Natl Marine Sci Ctr, Coffs Harbour, NSW 2450, Australia |
| 推荐引用方式 GB/T 7714 | Li, Xiaomei,Luo, Lan,Cai, Ying,et al. Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(42):9315-9323. |
| APA | Li, Xiaomei.,Luo, Lan.,Cai, Ying.,Yang, Wenjiao.,Lin, Lisha.,...&Zhao, Jinhua.(2017).Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,65(42),9315-9323. |
| MLA | Li, Xiaomei,et al."Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.42(2017):9315-9323. |
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