Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

doi:10.1016/j.bbrc.2011.01.006

	Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro
	Pei, Ying 1; Chen, Zhen-Ping 1; Ju, Huai-Qiang 1; Komatsu, Masaaki 2; Ji, Yu-hua 3; Liu, Ge 4; Guo, Chao-wan 4; Zhang, Ying-Jun5 ; Yang, Chong-Ren 5; Wang, Yi-Fei 1; Kitazato, Kaio 4
通讯作者	Wang, YF (reprint author), Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
	2011-02-11
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	405 期号:2 页码:186-191
摘要	Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Autophagy Pentagalloylglucose (Pgg) Hsv-1 Infections Anti-viral Activity
学科领域	Biochemistry & Molecular Biology ; Biophysics
DOI	10.1016/j.bbrc.2011.01.006
收录类别	SCI
语种	英语
WOS记录号	WOS:000287627500007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5569
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China 2.Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan 3.Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China 4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 8528521, Japan 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Pei, Ying,Chen, Zhen-Ping,Ju, Huai-Qiang,et al. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,405(2):186-191.
APA	Pei, Ying.,Chen, Zhen-Ping.,Ju, Huai-Qiang.,Komatsu, Masaaki.,Ji, Yu-hua.,...&Kitazato, Kaio.(2011).Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,405(2),186-191.
MLA	Pei, Ying,et al."Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 405.2(2011):186-191.

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