Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro
Pei, Ying1; Chen, Zhen-Ping1; Ju, Huai-Qiang1; Komatsu, Masaaki2; Ji, Yu-hua3; Liu, Ge4; Guo, Chao-wan4; Zhang, Ying-Jun5; Yang, Chong-Ren5; Wang, Yi-Fei1; Kitazato, Kaio4
2011-02-11
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
卷号405期号:2页码:186-191
摘要Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved.
关键词Autophagy Pentagalloylglucose (Pgg) Hsv-1 Infections Anti-viral Activity
资助信息National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; Ministry of Education (MOE)[211]; Fundamental Research Funds for the Central Universities; Tokyo Biochemical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology of Japan[22590274]
学科领域Biochemistry & Molecular Biology ; Biophysics
DOI10.1016/j.bbrc.2011.01.006
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000287627500007
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5569
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
2.Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
3.Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 8528521, Japan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Pei, Ying,Chen, Zhen-Ping,Ju, Huai-Qiang,et al. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,405(2):186-191.
APA Pei, Ying.,Chen, Zhen-Ping.,Ju, Huai-Qiang.,Komatsu, Masaaki.,Ji, Yu-hua.,...&Kitazato, Kaio.(2011).Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,405(2),186-191.
MLA Pei, Ying,et al."Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 405.2(2011):186-191.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201204090034.pdf(784KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Pei, Ying]的文章
[Chen, Zhen-Ping]的文章
[Ju, Huai-Qiang]的文章
百度学术
百度学术中相似的文章
[Pei, Ying]的文章
[Chen, Zhen-Ping]的文章
[Ju, Huai-Qiang]的文章
必应学术
必应学术中相似的文章
[Pei, Ying]的文章
[Chen, Zhen-Ping]的文章
[Ju, Huai-Qiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。