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题名: Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro
作者: Pei, Ying1; Chen, Zhen-Ping1; Ju, Huai-Qiang1; Komatsu, Masaaki2; Ji, Yu-hua3; Liu, Ge4; Guo, Chao-wan4; null(张颖君)5; Yang, Chong-Ren5; Wang, Yi-Fei1; Kitazato, Kaio4
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
关键词: Autophagy ; Pentagalloylglucose (PGG) ; HSV-1 infections ; Anti-viral activity
英文摘要: Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved.
出版日期: 2011-02-11
卷号: 405, 期号:2, 页码:186-191
DOI标识: 10.1016/j.bbrc.2011.01.006
语种: 英语
ISSN号: 0006-291X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5569
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
2.Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
3.Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 8528521, Japan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Pei, Y; Chen, ZP; Ju, HQ; Komatsu, M; Ji, YH; Liu, G; Guo, CW; Zhang, YJ; Yang, CR; Wang, YF; Kitazato, K.Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,405(2):186-191
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