Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata

doi:10.1016/j.steroids.2011.04.003

	Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata
	Li, Lei 1,2; Ni, Wei 1; Li, Xing-Rao 1; Hua, Yan 2; Fang, Ping-Lei 1; Kong, Ling-Mei 1; Pan, Li-Li 1; Li, Yan1 ; Chen, Chang-Xiang1 ; Liu, Hai-Yang1
通讯作者	Liu, HY (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650204, Yunnan, Peoples R China
	2011-09-01
发表期刊	STEROIDS
ISSN	0039-128X
卷号	76 期号:10-11 页码:1037-1042
摘要	By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first pentacyclic sterol glycoside with 6-6-6-5-6 fused rings. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis, including that of 2D NMR data, and the results of acidic hydrolysis. The cytotoxicity of the selected steroidal glycosides (1-4, 8, and 9) was evaluated in vitro against five human cancer cell lines. Compound 9 showed significant inhibitory activity against all five cell lines. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Tacca Subflabellata Taccaceae Taccasubosides A-d Cytotoxic Activity
学科领域	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI	10.1016/j.steroids.2011.04.003
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000294074700013
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5553
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.SW Forestry Univ, Fac Nat Resources, Kunming 650224, Peoples R China
推荐引用方式 GB/T 7714	Li, Lei,Ni, Wei,Li, Xing-Rao,et al. Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata[J]. STEROIDS,2011,76(10-11):1037-1042.
APA	Li, Lei.,Ni, Wei.,Li, Xing-Rao.,Hua, Yan.,Fang, Ping-Lei.,...&Liu, Hai-Yang.(2011).Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata.STEROIDS,76(10-11),1037-1042.
MLA	Li, Lei,et al."Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata".STEROIDS 76.10-11(2011):1037-1042.

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