Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii
Chen, Xuan-Qin1,2,3; Li, Yan1; Li, Kun-Zhi2; Peng, Li-Yan1; He, Juan1; Wang, Kou1; Pan, Zheng-Hong1; Cheng, Xiao1; Li, Ming-Ming1; Zhao, Qin-Shi1; Xu, Gang1
2011-10-01
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号59期号:10页码:1250-1253
摘要Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A-D (1-4), were isolated from the methanol extract of Hypericum beanii along with 16 known compounds. Their structures were established on the basis of spectroscopic and X-ray diffraction analysis. Hyperbeanols A-C were three stereoisomers different only at the relative configuration of C-4 and C-13, which were distinguished by the nuclear Oyerhauser effect spectroscopy (NOESY) spectroscopic data in combination with the single X-ray analysis of hyperbeanol A (1). The cytotoxic activity of hyperbeanols A D against the cancer cell lines SK-BR-3, HL-60, SMMC-7721, PANC-1, MCF-7, and K562 was also evaluated.
关键词Hypericum Beanii Acylphloroglucinol Hyperbeanol a Hyperbeanol b Hyperbeanol c Hyperbeanol d
资助信息973 project[2009CB522300]; National Natural Science Foundation of China[90813004, 20972167]; Innovation Foundation of Chinese Academy of Sciences[KSCX1-YW-R-24]; CAS
学科领域Pharmacology & Pharmacy ; Chemistry
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号WOS:000295391200007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5541
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Univ Sci & Technol, Biotechnol Res Ctr, Kunming 650224, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Chen, Xuan-Qin,Li, Yan,Li, Kun-Zhi,et al. Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(10):1250-1253.
APA Chen, Xuan-Qin.,Li, Yan.,Li, Kun-Zhi.,Peng, Li-Yan.,He, Juan.,...&Xu, Gang.(2011).Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii.CHEMICAL & PHARMACEUTICAL BULLETIN,59(10),1250-1253.
MLA Chen, Xuan-Qin,et al."Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii".CHEMICAL & PHARMACEUTICAL BULLETIN 59.10(2011):1250-1253.
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