Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi
Hu, Zhuo1; Zhan, Rui2,3; Du, Xue2; Su, Jia2; Li, Xiao-Nian2; Yang, Jian-Hong2; Zhang, Hai-Bo2; Li, Yan2; Sun, Han-Dong2; Li, Gan-Peng1; Pu, Jian-Xin2
通讯作者Li, GP (reprint author), Yunnan Nationalities Univ, Coll Chem & Biotechnol, Kunming 650031, Peoples R China
2011-12-01
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号59期号:12页码:1562-1566
摘要Five new ent-kaurane diterpenoids, isodonhenrins A-E (1-5), together with thirteen known ones were isolated from the aerial parts of Isodon henryi. Their structures were identified by means of extensive spectroscopic analysis, and the absolute configurations of 1 were determined by single-crystal X-ray diffraction. Most of the diterpenoids were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. Compound 17 showed significant inhibitory effects on five cell lines, and compounds 6, 9, 10, 11, 12 and 16 exhibited selective activity.
关键词Isodon Henryi Diterpenoid Isodonhenrin
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1055/s-0028-1088331
收录类别SCI ; IC
语种英语
WOS记录号WOS:000297392300020
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5535
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Nationalities Univ, Coll Chem & Biotechnol, Kunming 650031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Hu, Zhuo,Zhan, Rui,Du, Xue,et al. Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(12):1562-1566.
APA Hu, Zhuo.,Zhan, Rui.,Du, Xue.,Su, Jia.,Li, Xiao-Nian.,...&Pu, Jian-Xin.(2011).Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi.CHEMICAL & PHARMACEUTICAL BULLETIN,59(12),1562-1566.
MLA Hu, Zhuo,et al."Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi".CHEMICAL & PHARMACEUTICAL BULLETIN 59.12(2011):1562-1566.
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