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题名: Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi
作者: Hu, Zhuo1; Zhan, Rui2, 3; Du, Xue2; Su, Jia2; Li, Xiao-Nian2; Yang, Jian-Hong2; Zhang, Hai-Bo2; null(李艳)2; null(孙汉董)2; Li, Gan-Peng1; Pu, Jian-Xin2
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
关键词: Isodon henryi ; diterpenoid ; isodonhenrin
英文摘要: Five new ent-kaurane diterpenoids, isodonhenrins A-E (1-5), together with thirteen known ones were isolated from the aerial parts of Isodon henryi. Their structures were identified by means of extensive spectroscopic analysis, and the absolute configurations of 1 were determined by single-crystal X-ray diffraction. Most of the diterpenoids were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. Compound 17 showed significant inhibitory effects on five cell lines, and compounds 6, 9, 10, 11, 12 and 16 exhibited selective activity.
出版日期: 2011-12-01
卷号: 59, 期号:12, 页码:1562-1566
语种: 英语
收录类别: SCI ; IC
学科分类: Pharmacology & Pharmacy; Chemistry
ISSN号: 0009-2363
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5535
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Nationalities Univ, Coll Chem & Biotechnol, Kunming 650031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Hu, Z; Zhan, R; Du, X; Su, J; Li, XN; Yang, JH; Zhang, HB; Li, Y; Sun, HD; Li, GP; Pu, JX.Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi,CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(12):1562-1566
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